Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of varying severity. Its prevalence is influenced by geographical location and ethnicity. Initially thought to be less common and less severe in sub-Saharan Africa, 1 recent estimates based on medical schemes data suggest a prevalence of RA in South Africa of 0.5%. 2 The disease appears to be more common in urban than rural
Metronidazole is a widely used antibacterial and antiprotozoal agent for a number of conditions. Whilst its more common gastrointestinal side effects are well known, neurotoxicity remains under-recognised. Both central and peripheral neurological side effects have been described. This report describes a case of radiologically confirmed metronidazole-induced cerebellar ataxia in a cirrhotic patient with a review of the literature. Awareness of this side effect is essential for prompt recognition as early drug withdrawal leads to resolution in the majority of cases.
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