Method of hyperthermia and tumor size influence effectiveness of doxorubicin release from thermosensitive liposomes in experimental tumors

Willerding, Linus; Limmer, Simone; Hossann, Martin; Zengerle, Anja; Wachholz, Kirsten; Hagen, Timo L.M. ten; Koning, Gerben A.; Sroka, Ronald; Lindner, Lars H.; Peller, Michael

doi:10.1016/j.jconrel.2015.12.004

Cited by 54 publications

(67 citation statements)

References 40 publications

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“…6) and compared to earlier DOX values by HPLC (0.5 ± 0.1 ng/mg) [12]. [12]. Negative DOX concentration in muscle will be addressed in the discussion section.…”

Section: Resultsmentioning

confidence: 89%

“…fig 3). Assuming a temperature gradient inside the heated tumors [12] and assuming different tumor temperatures lead to different DOX concentrations, bisecting the heated tumors in a lateral tumor half closer to the laser light applicator and a medial tumor half was considered as an internal control. The DOX data of the bisected tumors showed a trend to higher DOX concentration at higher temperatures.…”

Section: Resultsmentioning

confidence: 99%

“…3. Laser induced hyperthermia HT was facilitated by using a laser-based, MRI compatible application system as described recently [12] (suppl. fig.…”

Section: Preparation Of Tslmentioning

confidence: 99%

“…Quantification of doxorubicin concentration in sample tissue by using HPLC is described in detail by Willerding et al [12]. Interday precision was investigated with three tissue samples (100 mg liver) spiked with 10, 5, and 2.5 ng/mg DOX (n = 4), respectively.…”

Section: Quantification Of Dox Concentration By Hplcmentioning

confidence: 99%

“…So far, lysolipid-based TSL (LTSL) with encapsulated doxorubicin (DOX) has entered human clinical trials [6,7]. An improved TSL-formulation based on the synthetic phosphatidyldiglycerol (DPPG 2 -TSL) has been successfully developed [8,9] and investigated in animal models [8,[10][11][12]. Key features are improved serum stability when compared to LTSL and a comparably fast release rate at a temperature above 40°C [9,13,14] which is in the typical range (40°C-43°C) used in combined chemotherapy/HT tumor treatment concepts [15].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Surrogate MRI markers for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in tumors

Peller

Willerding

Limmer

et al. 2016

Journal of Controlled Release

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“…6) and compared to earlier DOX values by HPLC (0.5 ± 0.1 ng/mg) [12]. [12]. Negative DOX concentration in muscle will be addressed in the discussion section.…”

Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

“…3. Laser induced hyperthermia HT was facilitated by using a laser-based, MRI compatible application system as described recently [12] (suppl. fig.…”

Section: Preparation Of Tslmentioning

confidence: 99%

Section: Quantification Of Dox Concentration By Hplcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Surrogate MRI markers for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in tumors

Peller

Willerding

Limmer

et al. 2016

Journal of Controlled Release

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Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

Gao

Jiang

Guo

et al. 2020

Adv Funct Materials

245

123

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Compared with conventional tumor photothermal therapy (PTT), mildtemperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild-temperature PTT might lead to toxic side effects. Glucose oxidase (GOx) consumes glucose, leading to adenosine triphosphate supply restriction and consequent HSP inhibition. Therefore, a combinational use of an HSP inhibitor and GOx not only enhances mildtemperature PTT but also minimizes the toxicity of the inhibitor. However, a GOx and HSP inhibitor-encapsulating nanostructure, designed for enhancing its mild-temperature tumor PTT efficiency, has not been reported. Thermosensitive GOx/indocyanine green/gambogic acid (GA) liposomes (GOIGLs) are reported to enhance the efficiency of mild-temperature PTT of tumors via synergistic inhibition of tumor HSP by the released GA and GOx, together with another enzyme-enhanced phototherapy effect. In vitro and in vivo results indicate that this strategy of tumor starvation and phototherapy significantly enhances mild-temperature tumor PTT efficiency. This strategy could inspire people to design more delicate platforms combining mildtemperature PTT with other therapeutic methods for more efficient cancer treatment.

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MRI‐Active Metal‐Organic Frameworks: Concepts for the Translation from Lab to Clinic

Peller

Lanza

Wuttke

2021

Advanced Therapeutics

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Metal‐organic frameworks (MOFs) are an emerging class of synthetic materials obtained by combining organic and inorganic chemistry. MOFs show peculiar properties such as well‐defined crystalline structures, systematic structural variation, high porosity and the possibility to chemically functionalize the pores. These properties are especially promising for designing MOF nanoparticles (NPs) with special functions. The desired functions can be introduced and modified with a chemical approach, by the choice of the inorganic and organic building blocks. All these features and the highest surface area of any porous material make MOF NPs ideal for the use as nanocarrier in biomedicine. So far, a wide variety of biomedical applications of MOF NPs have been already envisioned being supported by promising first in vitro and in vivo results. The ongoing development of MOF NPs is at the edge of basic science to biomedical applications. A major focus of biomedical research is already in cancer therapy using MOF NPs as theranostic nanocarrier. In this article, NP designs and MRI‐labelling concepts are pointed out and discussed in the perspective of facilitating their translation to clinical use. Clinical application is envisioned with a major focus on theranostic MOF NPs and MRI as the most promising imaging method.

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Method of hyperthermia and tumor size influence effectiveness of doxorubicin release from thermosensitive liposomes in experimental tumors

Cited by 54 publications

References 40 publications

Surrogate MRI markers for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in tumors

Surrogate MRI markers for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in tumors

Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

MRI‐Active Metal‐Organic Frameworks: Concepts for the Translation from Lab to Clinic

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