Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

Gao, Ge; Jiang, Yao‐Wen; Guo, Yuxin; Jia, Hao‐Ran; Cheng, Xiaotong; Deng, Yu; Yu, Xiaqing; Zhu, Ya‐Xuan; Guo, Haoyue; Sun, Wei; Liu, Xiaoyang; Zhao, Jing; Yang, Shuai; Yu, Zhi‐Wu; Raya, Fatima Maria Sierra; Liang, Guozheng; Wu, Fugen

doi:10.1002/adfm.201909391

Cited by 247 publications

(132 citation statements)

References 58 publications

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“…This is the principle behind the proposed cancer starvation therapy, which effectively starves the cells by depleting their glucose supply ( Kim and Dang, 2006 ; Li et al, 2018 ). This approach has stimulated much interest ( Fu et al, 2018 ; Yu et al, 2018 ; Xie et al, 2019 ) and the glucose oxidase GOx has attracted attention ( Fu et al, 2019 ; Yang et al, 2019 ; Gao et al, 2020 ; Ren et al, 2020 ) for its role in the oxidation of glucose to gluconic acid, a reaction that can be harnessed to restrict the glucose supply to tumor cells ( Jain, 2014 ; Gao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang

Chang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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The restriction of a tumor’s energy supply is proven to be an effective means of treatment. Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard. However, hypoxia, which is implicated in tumor growth, has been found to mediate resistance to this type of tumor starvation. Here, we describe the design and testing of a platelet membrane mimetic, PMS, consisting of mesoporous silica nanoparticles (MSNs) loaded with metformin (MET) as an inner layer and platelet membranes (PM) as an outer layer that inhibits oxygen consumption by the tumor cells’ respiratory pathways and enhances the effectiveness of GOx. MET directly inhibits the activity of complex I in mitochondrial electron transport and is thus a potent inhibitor of cell respiration. PMS target tumor tissue effectively and, once internalized, MET can inhibit respiration. When oxygen is plentiful, GOx promotes glucose consumption, allowing amplification of its effects on tumor starvation. This combination of respiratory suppression by PMS and starvation therapy by GOx has been found to be effective in both targeting tumors and inhibiting their growth. It is hoped that this strategy will shed light on the development of next-generation tumor starvation treatments.

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Section: Introductionmentioning

confidence: 99%

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang

Chang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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“…Starvation therapy blocking the nutrient metabolism pathways deprives cancer cells of energy, which meanwhile restricts adenosine triphosphate supply to inhibit HSPs and replenishes H 2 O 2 for intensified PTT/CDT (G. Gao et al, 2020). For instance, a versatile antitumor copper molybdenum sulfide (Cu 2 MoS 4 ) was loaded with glucose oxidase (GOx) for cooperative PTT/CDT/immunotherapy/starvation therapy (Chang et al, 2019).…”

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Yao

Fang

Yao

et al. 2020

WIREs Nanomed Nanobiotechnol

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Given the diversity, complexity, and heterogeneity of persistent tumors, traditional nanoscale monotherapeutic systems suffer from dissatisfactory curative efficiency with incidence of metastasis or relapse. In parallel, the trend of clinical research on the basis of nanomedicines has increasingly shifted from monotherapy toward combinatorial therapy for admirable synergetic performances. In this regard, cutting‐edge nanomedicines harnessing photothermal‐chemodynamic bimodal therapy (PTT/CDT) have opened up a highly‐efficient and relatively‐safe cancer theranostic paradigm. Still, the integration of PTT/CDT functional units into one nanomedicine remains a herculean but meaningful task to achieve notable super‐additive effects. This review aims to elucidate underlying synergistic interactions of PTT/CDT and highlight intriguing designs of nanomedicines for PTT/CDT including nanomaterial selection, performance optimization, multimodal therapy, visualization strategies, and targeting strategies. Furthermore, an outlook on further improvements of PTT/CDT is provided, emphasizing significant scientific issues that require remediation for clinical translation. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…The inorganic PTAs include metal or metal-containing nanomaterials including gold nanostructures [ 11 , 12 ], palladium-based nanostructures [ 13 – 15 ], iron or copper-containing nanoparticles (NPs) [ 16 – 19 ], transition metal chalcogenides [ 20 ], and quantum dots [ 21 , 22 ]. On the other hand, organic materials [ 23 ] including near-infrared (NIR) dyes represented by cyanine dyes [ 24 – 32 ], conjugated polymers (e.g., polydopamine (PDA), polyaniline, polypyrrole, and poly(3,4-ethylenedioxythiophene)) [ 33 – 36 ], and some carbon-based nanomaterials (most of them are organic materials; as represented by graphite-related nanostructures) [ 37 – 41 ] have also been utilized for PTT.…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

131

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Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

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Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

Cited by 247 publications

References 58 publications

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Low-Temperature Photothermal Therapy: Strategies and Applications

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