Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form

Vanaja, N.; Preethi, Ch.; Manjunath, S.Y.; Pal, Krishanu

doi:10.5958/2231-5675.2015.00030.7

Cited by 10 publications

(1 citation statement)

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“…Various analytical methods are reported for estimation of TMS in pharmaceutical dosage form. Literature survey reveals UV for telmisartan in bulk [4][5][6] , difference in spectrophotometry 7 , spectrophotometry in combination with other drugs [8][9][10][11][12][13][14][15] , colorimetry [16][17][18] , HPLC [19][20][21][22][23][24][25][26][27] , stability indicating RP-HPLC [28][29][30] Forced degradation 31 , are reported for estimation of telmisartan. A colorimetric analysis is a simple spectrophotometric analysis used to figure out the amount of a colored component present in a solution.…”

Section: Figure 1: Structure Of Telmisartanmentioning

confidence: 99%

Development and Validation of Extractive Spectrophotometric Methods for the Estimation of Telmisartan by Using Smartphone Application

Saiyed

Jadeja²,

Mashru³

2022

J. Drug Delivery Ther.

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Two simple, sensitive, accurate, precise and reproducible extractive colorimetric methods were developed for estimation of Telmisartan in bulk and pharmaceutical dosage form. These methods are based on the formation of colored ion-pair complex of Telmisartan with Bromocresol green (BCG) and Bromocresol purple (BCP) dyes in acidic medium. The complex was extracted in chloroform and estimated quantitatively at 421 nm and 411 nm for BCG and BCP dyes respectively. For estimation of TMS present in the sample, estimation was also done by using Smartphone Application known as PhotoMetrix Pro. Beer Lambert’s law was obeyed over a range of 4-12 μg/ml for TMS with BCG dye by UV (r²= 0.9997) and PhotoMetrix (r²= 0.997) and for BCP dye it was obeyed over a range of 2-10 μg/ml by UV (r²= 0.999) and PhotoMetrix (r²= 0.998). The developed method was successfully applied for estimation of TMS in three commercial product tablet formulation without interference from common additives. The developed method was validated according to ICH Q2 guideline for linearity, range, accuracy, and precision. Comparison for both method UV and PhotoMetrix was done by performing t-test, and results show that there is no significant difference between both methods and hence Photometrix can be used as an alternative to UV for routine analysis of TMS. Keywords: Telmisartan, Bromocresol green, Bromocresol purple, Acidic dyes, Colorimetry, UV spectrophotometry, PhotoMetrix.

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Section: Figure 1: Structure Of Telmisartanmentioning

confidence: 99%

Development and Validation of Extractive Spectrophotometric Methods for the Estimation of Telmisartan by Using Smartphone Application

Saiyed

Jadeja²,

Mashru³

2022

J. Drug Delivery Ther.

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A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

AL-Japairai

Chatterjee

Mahmood

et al. 2021

RJPT

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The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.

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Evaluation of Dextromethorphan HBr and Glyceryl Guaiacolate mixture in syrup preparation by Derivative Spectrophotometry Methods

Muchlisyam

Permata

Syahputra

2022

RJPT

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The derivative spectrophotometric methods are the goal of evaluating the simultaneous level of Dextromethorphan HBr and Glyceryl Guaiacolate mixture in Syrup. The determination of the mixture is used the derivative spectrophotometry method with methanol-water (50:50) for Dextromethorphan HBr and Glyceryl Guaiacolate. The derivative spectrophotometric method on 1st derivatization with ∆λ 2 nm have wavelength 263.6 nm for Dextromethorphan HBr and 2nd derivatization with ∆λ 2 nm at 285 nm for Glyceryl guaiacolate, The locally producted syrup samples met the level requirements mixture of Dextromethorphan and Glyceryl guaiacolate less than 90.0% and not over 110.0% of the amount stated on the label. The validation test showed that these two methods had met the validation parameter. The derivative spectrophotometry method was used to determine a mixture of Dextromethorphan HBr and Glyceryl guaiacolate and fulfilling the validation requirements and level requirements according to USP 30.

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Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form

Cited by 10 publications

References 0 publications

Development and Validation of Extractive Spectrophotometric Methods for the Estimation of Telmisartan by Using Smartphone Application

Development and Validation of Extractive Spectrophotometric Methods for the Estimation of Telmisartan by Using Smartphone Application

A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

Evaluation of Dextromethorphan HBr and Glyceryl Guaiacolate mixture in syrup preparation by Derivative Spectrophotometry Methods

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