Metastatic Prostate Cancer (with Prostate-Specific Antigen of 9996) Presenting as Obstructive Jaundice

Cole, A. C. E.; Mendelblatt, David; Aguayo, José Luis; Mathew, Arun Peter; Martín, Elena; Vesely, David L.

doi:10.1016/s0002-9629(15)40699-8

The American Journal of the Medical Sciences

2000

DOI: 10.1016/s0002-9629(15)40699-8

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Metastatic Prostate Cancer (with Prostate-Specific Antigen of 9996) Presenting as Obstructive Jaundice

A. C. E. Cole

David Mendelblatt

José Luis Aguayo

et al.

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Cited by 10 publications

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A patient with obstructive jaundice secondary to intrahepatic bleeding caused by prostate cancer metastasis

Adawi

2021

Urology Case Reports

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A metastatic disease causes jaundice is not uncommon and usually related to direct tumor invasion to the biliary tree or massive intrahepatic metastasis. Cholestasis secondary to non-traumatic intrahepatic bleeding caused by metastasis from prostate cancer is never been reported in the literature. We present the first case of a-71-years-old patient developed Cholestasis due to spontaneous intrahepatic bleeding caused by metastasis from prostate cancer that was successfully treated conservatively. Prostatic cancer causes liver metastasis carries worse prognosis and compression of the intrahepatic biliary ducts can have long term unsatisfactory outcomes.

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A patient with obstructive jaundice secondary to intrahepatic bleeding caused by prostate cancer metastasis

Adawi

2021

Urology Case Reports

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Paraneoplastic Liver Dysfunction in Prostate Cancer

Shah

2006

Journal of Pain and Symptom Management

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Delivery of Sphingosine 1-Phosphate from Poly(ethylene glycol) Hydrogels

et al. 2006

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While protein growth factors promote therapeutic angiogenesis, delivery of lipid factors such as sphingosine 1-phosphate (S1P) may provide better stabilization of newly formed vessels. We developed a biomaterial for the controlled delivery of S1P, a bioactive lipid released from activated platelets. Multiarm poly(ethylene glycol)-vinyl sulfone was cross-linked with albumin, a lipid-transporting protein, to form hydrogels. The rate of S1P release from the materials followed Fickian kinetics and was dependent upon the presence of lipid carriers in the release solution. Delivery of S1P from RGD-modified hydrogels increased the cell migration speed of endothelial cells growing on the materials. The materials also induced angiogenesis in the chorioallantoic membrane assay. Our data demonstrate that the storage and release of lipid factors provides a new route for the induction of angiogenesis by artificial materials.

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Metastatic Prostate Cancer (with Prostate-Specific Antigen of 9996) Presenting as Obstructive Jaundice

Cited by 10 publications

References 10 publications

A patient with obstructive jaundice secondary to intrahepatic bleeding caused by prostate cancer metastasis

A patient with obstructive jaundice secondary to intrahepatic bleeding caused by prostate cancer metastasis

Paraneoplastic Liver Dysfunction in Prostate Cancer

Delivery of Sphingosine 1-Phosphate from Poly(ethylene glycol) Hydrogels

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