Metastasis to the Larynx: Report of a Case and Review of the Literature

Disappearance of Metastatic Renal Cell Carcinoma to the Base of the Tongue after Systemic Administration of Interferon-Alpha

“…nearly always occurred in the terminal stages of cancer and were asso ciated with widespread métastasés [2,4,5], as in our case, solitary metastatic renal cell carcinoma to the larynx was also reported [3].…”

“…This fact, at least to a certain extent, may be due to the position of the larynx as a terminal organ of the normal blood and lymphatic circulation [2], and, conse quently, it may be difficult for the tumor emboli to reach those termi nal organs. Furthermore, unexplained immunity of the larynx to cir culating tumor cells was assumed [3], Though laryngeal métastasés Disappearance of Metastatic Renal Cell Carcinoma to the Tongue by IFN-a…”

Secondary Malignant Melanoma of the Larynx

“…At the Mayo Clinic, from 1941 to 1971, only 2 cases of secondary cancers of the larynx have been seen [ Whicker et al, 1972], During the period from January 1966 through December 1982, 2 cases of laryngeal metastases of malignant melanoma have been observed at the Section of Pathology of the ENT Department of Padua University in a series of 2,874 primary and secondary ma lignant neoplasms of the larynx and hypopharynx recorded in the same period (0.07%). A review of the literature resulted in the identification of 79 previously reported cases.…”

“…However, an isolated met astatic deposit to the larynx can occur [Fields, 1966;Whicker et al, 1972] and ought to be carefully evaluated. Treatment of a second ary lesion of the larynx is in fact justified when other organs have not yet been affected.…”

Laryngeal Prostatic Cancer Metastases: An Underestimated Route of Metastases?

“… 3–7 Melanomas and hypernephromas have been found to be the most common tumors in case of laryngeal metastasis diagnosis, 8 followed by breast, lung, and colon tumors (Table I). 1–7,9–75 Laryngeal metastases due to prostatic cancer have been found to be a rare event in clinical practice. Only 13 observations of laryngeal prostatic metastases have been reported in the literature (Table II).…”