Secondary Malignant Melanoma of the Larynx

Abstract

2 cases of laryngeal metastases from malignant melanoma of the skin have been observed at the ENT Department of Padua University during the last 17 years (from January 1966 through December 1982). A critical review of the pertinent literature is made and the metastatic spread to the larynx is also discussed. The importance of routine indirect laryngoscopy in neoplastic patients ‘at risk’ is underlined.

Disappearance of Metastatic Renal Cell Carcinoma to the Base of the Tongue after Systemic Administration of Interferon-Alpha

“…nearly always occurred in the terminal stages of cancer and were asso ciated with widespread métastasés [2,4,5], as in our case, solitary metastatic renal cell carcinoma to the larynx was also reported [3].…”

“…This fact, at least to a certain extent, may be due to the position of the larynx as a terminal organ of the normal blood and lymphatic circulation [2], and, conse quently, it may be difficult for the tumor emboli to reach those termi nal organs. Furthermore, unexplained immunity of the larynx to cir culating tumor cells was assumed [3], Though laryngeal métastasés Disappearance of Metastatic Renal Cell Carcinoma to the Tongue by IFN-a…”

“…Of the metastatic carcinoma to the larynx, renal cell carcinoma is the second most common source of primary malignancy [2,5], and it has been stressed that since the number of reported cases of laryngeal métastasés is lower than their actual frequency [2,4], it is worthwhile performing routine indirect laryngoscopy in patients with renal cell carcinoma having symptoms such as hemosputum, even if these patients have lung métastasés.…”

Postirradiation laryngeal osteosarcoma: Case report and literature review

“…The most common primary tumor is melanoma of the skin, [22][23][24][25] and the most common site of involvement is the subglottis, followed by synchronous multiple sites. The prognosis is unfavorable, because laryngeal metastasis usually is associated with generalized disease in the late stages.…”

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

“…It accounts for less than 1% of all melanomas in the Western world and less than 5% of all sinonasal tract tumors [1,2,3,4]. Due to this rare incidence of SNMMM, previous studies have mostly involved case reports [5]. Other published studies of SNMMM have focused primarily on treatment options and imaging features [6,7].…”