Laryngeal Prostatic Cancer Metastases: An Underestimated Route of Metastases?

Prescher, Andreas; Schick, Bernhard; Stütz, Arndt; Brors, Dominik

doi:10.1097/00005537-200208000-00026

Cited by 28 publications

(22 citation statements)

References 48 publications

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“…As disadvantage of ossification it should be noted that cartilages of the laryngeal skeleton are damaged by laryngeal cancer mainly in ossified and vascularized sites (Olszewski, ; Kirchner, ; Tillmann and Paulsen, ; Paulsen and Tillmann, ). Furthermore, the ossified laryngeal framework is not only destroyed by invading laryngeal cancer cells, but also a target of metastases of primary tumors which prefer bone, such as for example prostatic cancer (Prescher et al, ).…”

Section: Discussionmentioning

confidence: 99%

Special pattern of endochondral ossification in human laryngeal cartilages: X‐ray and light‐microscopic studies on thyroid cartilage

et al. 2014

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Endochondral ossification is a process that also occurs in the skeleton of the larynx. Differences in the ossification mechanism in comparison to growth plates are not understood until now. To get deeper insights into this process, human thyroid cartilage was investigated by the use of X-rays and a series of light-microscopic stainings. A statistical analysis of mineralization was done by scanning areas of mineralized cartilage and of ossification. We detected a special mode of endochondral ossification which differs from the processes in growth plates. Thyroid cartilage ossifies very slowly and in a gender-specific manner. Compared with age-matched women, bone formation in thyroid cartilage of men is significantly higher in the age group 41-60 years. Endochondral ossification is prepared by internal changes of extracellular matrix leading to areas of asbestoid fibers with ingrowing cartilage canals. In contrast to growth plates, bone is deposited on large areas of mineralized cartilage, which appear at the rims of cartilage canals. Furthermore, primary parallel fibered bone was observed which was deposited on woven bone. The predominant bone type is cancellous bone with trabeculae, whereas compact bone with Haversian systems was seldom found. Trabeculae contain a great number of reversal and arresting lines meaning that the former were often reconstructed and that bone formation was arrested and resumed again with advancing age. It is hypothesized that throughout life trabeculae of ossified thyroid cartilage undergo adaptation to different loads due to the use of voice.

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Section: Discussionmentioning

confidence: 99%

Special pattern of endochondral ossification in human laryngeal cartilages: X‐ray and light‐microscopic studies on thyroid cartilage

et al. 2014

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“…The larynx is a rare but potential site of prostate carcinoma metastasis [1]. The tumor cells first metastasize to the haematopoietic tissue within the laryngeal cartilages, followed by local destruction and subsequent development of a perilaryngeal soft tissue mass.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent primary tumors that metastasize to the larynx include melanoma, renal, colorectal, breast and lung. Prostate carcinoma metastasis to the larynx is rare, with fewer than 20 cases reported [1].…”

Section: Introductionmentioning

confidence: 99%

Asymptomatic metastasis to cricoid from prostate carcinoma: an incidental finding detected on 18F-choline PET/CT

Sinha

Loi

et al. 2015

Jpn J Radiol

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“…The tumors which most often metastasize to the larynx are the melanoma and the clear cell renal carcinoma. There are, however, reports of colon, pancreas, breast and prostate cancer metastases 1,3 . The supraglottis is the most affected site by these metastases, and the glottis is the less frequent one Laryngeal involvement by the tumor may or may not cause symptoms, hoarseness and stridor.…”

Section: Discussionmentioning

confidence: 99%