Metastasis of squamous cell carcinoma of the oral tongue

Sano, Daisuke; Myers, Jeffrey N.

doi:10.1007/s10555-007-9082-y

Cited by 320 publications

(289 citation statements)

References 194 publications

(212 reference statements)

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“…11,15,16,[18][19][20]22 The biologic rationale for using this particular cutoff level needs to be understood, but the consistency of results across studies is noteworthy. We also confirmed previous reports indicating the prognostic value of tumor size 11,23,24 and the lack of an association between survival and tumor grade. 12,[25][26][27] The literature regarding histologic features and prognosis of tongue cancer is rather voluminous and goes back at least 20 years; however, it is important to point out several differences between our report and other studies published to date.…”

Section: Discussionsupporting

confidence: 91%

Invasion characteristics of oral tongue cancer

Goodman¹,

Liu²,

Ward³

et al. 2009

Cancer

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Background This study explored the blood transfusion patterns, SCD complications, utilization of iron chelation therapies (ICT), healthcare resource use, and costs in pediatric, transitioning (18 years old) and adult patients with SCD. Procedure Data from Florida (1998–2009), New Jersey (1996–2009), Missouri (1997–2010), Kansas (2001–2009), and Iowa (1998–2010) state Medicaid were used. Patients with ≥2 SCD diagnoses and ≥1 transfusion event were included. Rates of transfusion events, SCD complications, and proportion of eligible patients receiving ICT were calculated. ICT eligibility was defined as receiving ≥10 transfusions over lifetime. SCD complications included pain, pulmonary event, infection event, renal, cardiovascular, stroke, leg ulcers, and avascular necrosis. Regressions were used to assess risk factors for transfusion and identify the main drivers of costs. Results The sample included 3,208 patients. The transfusion rate increased from 1‐year‐old to a peak at 16 years old, then dropped until age 26 and remained stable thereafter. In contrast the frequency of diagnoses for SCD complications increased markedly after age 16. Post‐transition patients (≥18 years old) were significantly associated with fewer transfusions (odds ratio: 0.80, P = 0.002). Among eligible patients for ICT, there was no statistically significant difference in total cost between the ICT and no ICT groups (adjusted cost difference, $136, P = 0.114). Conclusions Patients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer 2013; 60: 828–835. © 2013 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Invasion characteristics of oral tongue cancer

Goodman¹,

Liu²,

Ward³

et al. 2009

Cancer

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“…A primary cause for the unfavorable prognosis is patient death from the cancer metastasized at regional and distant sites (2)(3)(4)(5). Squamous cell carcinoma (SCC) accounts for approximately 90% of oral and oropharyngeal malignancies in the United States and tongue is a common site of the malignant diseases (6,7). The rate of nodal metastasis is higher in tongue cancer patients than oral cavity cancer patients whose rate is 30% on their initial evaluation (8,9).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis

Tanaka

Imamura

Yoneda

et al. 2016

International Journal of Oncology

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Abstract.To study the role of TNF-α in tongue cancer metastasis, we made highly metastatic cells from a human oral squamous cell carcinoma cell line (SAS) by repeating the passage in which the cells were injected into a nude mouse tongue and harvested from metastasized cervical lymph nodes. Cancer cells after 5 passages (GSAS/N5) increased invasive activity 7-fold in a TNF-α receptor 1 (TNFR1)-dependent manner and enhanced mRNA expression of TNF-α and TNFR1. In the highly metastatic cells, NF-κB activation was upregulated via elevated phosphorylation of Akt and Ikkα/β in the signaling pathway and secretion of TNF-α, active MMP-2 and MMP-9 increased. Suppression of increase of TNF-α mRNA expression and MMP secretion by NF-κB inhibitor NBD peptide suggested a positive feedback loop in GSAS/N5 cells; TNF-α activates NF-κB and activated NF-κB induces further TNF-α secretion, leading to increase of active MMP release and promotion of invasion and metastasis of the cells. GSAS/N5 cells that had been injected into the nude mouse tongue and harvested from metastasized lungs multiplied angiopoietin-like 4 (Angptl4) expression with enhanced migration activity, which indicated a possible involvement of Angptl4 in lung metastasis of the cells. These results suggest that TNF-α and Angptl4 promote metastasis of the oral cancer cells, thus, these molecules may be therapeutic targets for patients with tongue cancer. IntroductionThe American Cancer Society estimated 45,780 new cases of oral cavity and pharyngeal cancer, and 8,650 deaths from these tumors, in 2015 in the United States (1). By advances in surgery and radiation therapy, the 5-year survival rate for oropharyngeal cancer has increased to 66%, but the rate is still unsatisfactory in comparison with some other site cancers including prostate, thyroid and breast; the rates of these types of cancer are >90% (1). A primary cause for the unfavorable prognosis is patient death from the cancer metastasized at regional and distant sites (2-5). Squamous cell carcinoma (SCC) accounts for approximately 90% of oral and oropharyngeal malignancies in the United States and tongue is a common site of the malignant diseases (6,7). The rate of nodal metastasis is higher in tongue cancer patients than oral cavity cancer patients whose rate is 30% on their initial evaluation (8,9). Several studies have shown a high rate of occult nodal metastasis (20-40%) in tongue SCC patients with no evidence of regional spread on clinical or radiographic evaluation (8,10-15). There is a tendency that tongue cancer increases in young females in recent 2-3 decades (16-18). Thus, metastasis suppression is a main and urgent subject in the treatments of patients with tongue SCC.The process of metastasis is complex and involves tumor growth, the extra-cellular matrix breakdown, invasion to the vessels, escape from immune surveillance, transport to other sites with adhesion to the vessel, subsequent invasion into an organ where tumor cells proliferate, grow and spread. Various molecules participate in the pr...

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“…Despite being visibly located in the oral cavity, >50% patients at diagnosis present with advanced stage III or IV according to the tumor-node metastasis classification of malignant tumors system (3). Despite improvements in surgery, radiotherapy and chemotherapy, the 5-year survival rate for patients with TSCC remains poor, mainly due to regional recurrence and lymph node metastasis (4,5). An accumulating number of studies suggest that TSCC arises as a result of oncogene activation or tumor suppressor gene inactivation (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

Chen

2016

Oncology Letters

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Metastasis of squamous cell carcinoma of the oral tongue

Cited by 320 publications

References 194 publications

Invasion characteristics of oral tongue cancer

Invasion characteristics of oral tongue cancer

Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

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