Metallodrugs in Medicinal Inorganic Chemistry

Mjos, Katja Dralle; Orvig, Chris

doi:10.1021/cr400460s

Cited by 1,068 publications

(865 citation statements)

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“…[3] In past decades, they scrutinized various transition metal compounds and found many structural patterns with enhanced activity toward cisplatin resistant tumor cells. [4] Nevertheless, quest for new highly active species with reduced side-effects is still ongoing. Our investigation follows the fundamental work of Romão et al, who established the allyl [(η 3 -C3H5)Mo(CO)2L2Br], cyclopentadienyl and indenyl molybdenum compounds [(η 5 -Cp')Mo(CO)2L2][BF4] (Cp': Cp = C5H5, Ind = C9H7), where L2 is N,N-, S,S-or P,P-chelating ligand, as new class of highly cytotoxic species against several tumor cell lines.…”

Section: Introductionmentioning

confidence: 99%

“…[7] The cytotoxicity of the molybdenum compounds seems to correlate mainly with nature of coordinated chelating ligand while the substitution in the π-coordinated ligand play only minor role. [8,9] High activity was observed for complexes baring 1,10-phentanthroline (phen) and its 4,7-diphenyl derivative (4,. However, main drawback of these complexes lay in their poor solubility in water that embarrasses their pharmaceutical application.…”

Section: Introductionmentioning

confidence: 99%

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Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

et al. 2016

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(2016). Highly water-soluble cyclopentadienyl and indenyl molybdenum(II) complexes -second generation of molybdenum-based cytotoxic agents. European Journal of Inorganic Chemistry, 2016Chemistry, (4), 519-529. doi:10.1002 This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving". Ondřej Mrózek, [a] Lucie Šebestová, [b] Jaromír Vinklárek,* [a] Martina Řezáčová, [c] Aleš Eisner, [b] Zdeňka Růžičková, [a] and Jan Honzíček [d] Abstract [BF4]2 were determined by the X-ray crystallography. All synthesized compounds exhibit increased activity against human leukemia cell lines MOLT-4 and HL-60. They are about one order of magnitude more active than cisplatin. This study has proven that modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for a design of novel highly cytotoxic active species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

et al. 2016

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“…The success of Pt-based anticancer drugs has spurred intense research activity directed towards development of new metal-based antitumor agents [1][2][3] . Among few others, Ti has emerged as a promising antineoplastic metal 4 .…”

Section: ■ Introductionmentioning

confidence: 99%

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)

et al. 2015

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“…Transition metal complexes are of interest since they display a wide variety of application in fields ranging from materials science and catalysis to biological activity [1].…”

Section: Introductionmentioning

confidence: 99%

“…UV-visible absorption spectroscopy and circular dichroism spectroscopy allow us to assign a D configuration to complex (1).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Activity of Cobalt(iii) Complex With Phenanthroline and Maltose

Parada

Atria

Wiese

et al. 2014

J. Chil. Chem. Soc.

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The mononuclear cobalt(III) complex derived from 1,10-phenanthroline and maltose ([Co(phen) 2 maltose]Cl 2 •3H 2 O) (1) has been synthesized and characterized in aqueous solution. Its characterization was based on its optical and spectroscopic properties.The antimicrobial activity of this complex was screened in vitro against the microorganisms Escherichia coli DH5a, Salmonella enterica sv Enteritidis ISP/953, Klebsiella pneumoniae RYC492, Pseudomonas aeruginosa PAO1, Enterococcus faecalis ATCC 29212, Bacillus cereus GCA234, Micrococcus sp. Staphylococcus aureus ATCC25923.Complex (1) showed antibacterial activity with a bacteriostatic effect over Gram positive and negative bacteria. The cytotoxicity of complex (1) was tested in vitro on human embryonic kidney cells.Keywords: Carbohydrate-cobalt(III) complexes; circular dichroism; antibacterial activity.e-mail: jparada@ciq.uchile.cl INTRODUCTIONTransition metal complexes are of interest since they display a wide variety of application in fields ranging from materials science and catalysis to biological activity [1].From the biological point of view, several studies have shown that the complexes may have antibacterial, antifungal and antitumor activity [2].The biological activity of metal complexes is highly dependent on the nature of the metal ions and the donor sequence of the ligands because different ligands exhibit different biological properties [3].An interesting group of ligands are the carbohydrates [4], whose complexes have shown significant antimicrobial activity against Gram-positive and Gramnegative bacterial strains as well as a few fungal strains [5]. Poller and Parkin reported the synthesis of organometallic derivatives of sucrose (lead, tin and germanium). In that study organotin was found to exhibit higher biocidal activities than would be expected from the tin content [6].A few sugar-cobalt complexes with antibacterial activity have been reported. An important example is grafted PVA polymer with a derivative of erythro-ascorbic acid (pentulosono-lactone-2,3-enedianisoate) reported by Salih et al. It was evaluated for antimicrobial properties against four pathogenic bacteria (Escherichia coli, Klebsiella pneumonae, Staphylococcus aureus, Staphylococcus albus) and fungi (Aspergillus niger, yeast). This cobalt complex showed good activity against the various microbial isolates [7].1,10-Phenanthroline is also one of the biologically important ligands, and several studies show that this ligand and a number of its complexes are effective against various strains of microorganisms. Here the synthesis of the mixed ligand cobalt complex [Co(phen) 2 maltose] Cl 2 ·3H 2 O (1), as well as its spectral features and optical activity are reported.UV-visible absorption spectroscopy and circular dichroism spectroscopy allow us to assign a D configuration to complex (1).The complex was also screened for antibacterial activity against Gram positive and Gram-negative bacteria. We determined the antibacterial effects and evaluated their cytotoxic effect on h...

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Metallodrugs in Medicinal Inorganic Chemistry

Cited by 1,068 publications

References 231 publications

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)

Synthesis, Characterization and Antibacterial Activity of Cobalt(iii) Complex With Phenanthroline and Maltose

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Metallodrugs in Medicinal Inorganic Chemistry

Cited by 1,068 publications

References 231 publications

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Synthesis, Characterization and Antibacterial Activity of Cobalt(iii) Complex With Phenanthroline and Maltose

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Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)