Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

Abstract

Research data are not shared.

New anti-cancer explorations based on metal ions

“…The synergistic action of these two methods led to the massive accumulation of lipid peroxides. Zhou et al [ 57 ] designed and prepared HMPB/ML210@TA-BLM-Fe 3+ nano-composites. After degradation in tumor cells, it would release ML210, effectively inhibiting the activity of GPX4 and activating the ferroptosis pathway.…”

“…Producing reactive oxygen by Fenton reaction Fe 3 O 4 /Gd 2 O 3 @CDDP@LF/RGD2 Fe 3 O 4 , CDDP [49] Gox@MOF(Fe)@CCM Fe 2+ , Fe 3+ , GOx [50] AuFCSP MOFs Fe 2+ , Fe 3+ , Au NPs [51] Inhibiting the activity of GXP4 RSL3@COF-Fc Fc, RSL3 [56] HMPB/ ML210@TA-BLM-Fe 3+ Fe 2+ , Fe 3+ , ML210 [57] Consuming intracellular GSH CA-OH-Fe 3+ /Gd 3+ @P-SS-D Fe 2+ , Fe 3+ , CA [58] siMCT4-PAMAM-PEG-TK-Fc@DEM Fc, DEM, siMCT4 [59] FPBC@SN Fe 2+ , Fe 3+ , SRF, NLG919 [60] Inhibiting the activity of System Xc-Ce6-Erastin Erastin [66] SSZ-Fe 2+ @DSSD Fe 2+ , SSZ [67] MIL-101(Fe)@SRF Fe 2+ , Fe 3+ , SRF [68] Delivering exogenous lipid peroxides IO-LAHP IO NPs, LAHP [71] RSL3@mPEG-PLys-AA RSL3, AA [72] Lecithin@FAC Fe 2+ , Fe 3+ , Lecithin [73] H 2 O 2 are crucial to the above process. GPX4 is a selenoprotein that catalyzes glutathione to convert lipid peroxides into lipid alcohols [52], effectively removing the accumulation of lipid peroxides in cells and providing antioxidant defense against ferroptosis [53].…”

Versatile polyphenolic platforms in regulating cell biology

“…As discussed before, polyphenols are capable of metal ion coordination, leading to ion enrichment and cell biology response in a cell-material contact manner. [183][184][185][186] Researchers have compared the effects of different ion-coordinated MPNs on the viability of HT1080 cells, which showed that only Fe 2+ / Fe 3+ could significantly induce cancer cell death (Fig. 14a).…”

“…In this way, MPNs are promising for inducing cancer cell ferroptosis and further enhancing antitumor efficiency. [183][184][185][186] More interestingly, researchers also explored the effects of different types of polyphenol-based MPN on intracellular lipid peroxide (LPO), ROS, and triphosphopyridine nucleotide/reduced triphosphopyridine nucleotide (NADP + /NADPH) content, which will reflect the oxidative damage degree. The results demonstrated that all the MPNs would induce oxidative damage on cells compared to the PBS control group, which could further sensitize the cells toward ferroptosis.…”

NIR-light-controlled G-quadruplex hydrogel for synergistically enhancing photodynamic therapy via sustained delivery of metformin and catalase-like activity in breast cancer

“…Still, nanoparticle–hydrogel superstructures integrated hemin nanoparticles into G-quadruplex hydrogel has not been reported yet. Our research group was dedicated to realize controlled release of drugs and synergy of chemotherapy/phototherapy by constructing antitumour drug delivery system [ [40] , [41] , [42] , [43] ]. ICG was the fluorophore with high biosafety approved by the Food and Drug Administration (FDA).…”