Metal‐Phenolic Networks Nanoplatform to Mimic Antioxidant Defense System for Broad‐Spectrum Radical Eliminating and Endotoxemia Treatment

Wei, Zhiwei; Wang, Liya; Tang, Chengqiang; Chen, Shengqiu; Wang, Zhou‐jun; Wang, Yilin; Bao, Jianxu; Xie, Yi; Zhao, Weifeng; Su, Baihai; Zhao, Changsheng

doi:10.1002/adfm.202002234

Cited by 81 publications

(52 citation statements)

References 79 publications

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“…[16] Inspired by the natural antioxidant defense system, numerous exogenous antioxidative nanomaterials have recently attracted great attention as a new type of antioxidant due to their improved stability, broad-spectrum antioxidant capabilities, and higher ROS scavenging efficiency. [17,18] Typically, a plethora of synthetic enzyme-mimicking nanomaterials (nanozymes), [19][20][21] such as metal nanoparticles, [22] metal oxide nanoparticles, [18,[23][24][25] carbon-based nanomaterials, [26] biomolecules, [27,28] and quantum dots, [29,30] have demonstrated multiple ROS scavenging capability and admirable antioxidant activity. [31] For example, to obtain enzyme-mimicking nanoparticles with good biocompatibility and quick renal clearance, Deng et al [22] prepared ultrasmall Cu 5.4 O nanoparticles with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability, which exhibited cytoprotective effects against ROS-mediated damage and significantly improved treatment outcomes in AKI and ROS-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation

Zhao

Wang

et al. 2021

Advanced Science

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Acute kidney injury (AKI), as a common oxidative stress-related renal disease, causes high mortality in clinics annually, and many other clinical diseases, including the pandemic COVID-19, have a high potential to cause AKI, yet only rehydration, renal dialysis, and other supportive therapies are available for AKI in the clinics. Nanotechnology-mediated antioxidant therapy represents a promising therapeutic strategy for AKI treatment. However, current enzyme-mimicking nanoantioxidants show poor biocompatibility and biodegradability, as well as non-specific ROS level regulation, further potentially causing deleterious adverse effects. Herein, the authors report a novel non-enzymatic antioxidant strategy based on ultrathin Ti 3 C 2 -PVP nanosheets (TPNS) with excellent biocompatibility and great chemical reactivity toward multiple ROS for AKI treatment. These TPNS nanosheets exhibit enzyme/ROS-triggered biodegradability and broad-spectrum ROS scavenging ability through the readily occurring redox reaction between Ti 3 C 2 and various ROS, as verified by theoretical calculations. Furthermore, both in vivo and in vitro experiments demonstrate that TPNS can serve as efficient antioxidant platforms to scavenge the overexpressed ROS and subsequently suppress oxidative stress-induced inflammatory response through inhibition of NF-B signal pathway for AKI treatment. This study highlights a new type of therapeutic agent, that is, the redox-mediated non-enzymatic antioxidant MXene nanoplatforms in treatment of AKI and other ROS-associated diseases.

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Section: Introductionmentioning

confidence: 99%

Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation

Zhao

Wang

et al. 2021

Advanced Science

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“…Oxidative stress, caused by an imbalance between antioxidative and oxidative systems, leads to permanent and irreversible damage of cellular components, such as proteins, lipids, and nucleic acids [ 1 ]. Furthermore, oxidative stress leads to diseases including Alzheimer’s disease [ 2 ], cardiac disease [ 3 ], atherosclerosis [ 4 ], kidney disease [ 5 ], sepsis [ 6 ], cancer [ 7 ], and inflammatory diseases (e.g., periodontal disease and inflammatory bowel disease) [ 8 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Ma¹,

Gong²,

Ogino³

et al. 2022

Beilstein J. Nanotechnol.

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Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inﬂammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study oﬀers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants.

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“…[34] By virtue of its antioxidative activity, several TA-containing nanosystems have been developed to combat oxidative stress. [35,36] Moreover, TA-based MOFs coating could facilitate the endosomal escape of nanoparticles via protonsponge effect. [37] We suspect that these properties are rather meaningful for siRNA delivery and anti-RA therapy, while such attempt has yet been made so far.…”

Section: Introductionmentioning

confidence: 99%

Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy

Guo

Zhong

Liu

et al. 2022

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cell immersion. The progress of RA causes obvious joint pain to patient, resulting in joint destruction, bone and cartilage damage, and ultimate joint disability. RA is still incurable, and current treatment drugs can only alleviate symptoms, such as disease-modifying anti-rheumatic drugs, non-steroidal anti-inflammatory drugs, glucocorticoids (GCs), and biological agents. [2] However, most of these drugs require long-term administration, which not only brings financial burden to patients but also causes a series of adverse effects. Therefore, it is urgently desired to develop etiological treatments to cure RA based on the pathogenesis of the disease. Substantial evidences have revealed that autoantigens are important initiation factor of RA development, and macrophages play an important role in the progression of the disease. [3,4] The autoantigens include citrullinated peptides/ proteins and biomacromolecules modified by the overproduced reactive oxygen and nitrogen species (RONS), [5][6][7] which stimulate body's immune cells to secrete antibodies. Immune complexes of antibodies-autoantigens binding are then formed and tend to deposit in joint site to induce inflammation and recruit macrophages. [3] The recruited macrophages in RA microenvironment are mainly polarized to pro-inflammatory M1 phenotype with abundant cytokines secretion and RONS generation via respiratory burst, giving a positive feedback loop to exacerbate inflammation. [8,9] Thus, macrophages have been recognized as an important therapeutic target, and synergistic elimination of cytokines and RONS is a promising strategy for RA therapy.Nanomedicine has emerged as a robust strategy for targeted RA therapy. By virtue of the leaky vasculature formed during the progression of RA, nanoparticles with specific size range can be passively accumulated into inflamed synovial tissues through the defined extravasation through leaky vasculature and subsequent inflammatory cell-mediated sequestration (ELVIS) effect. [10,11] Moreover, the M1 polarized macrophages overexpress various receptors on cell membrane (e.g., folate receptor, scavenger receptor, CD44), which provides an opportunity for the design of active targeting systems via ligands modification on nanoparticle surface. For example, we recently reported hyaluronic acid (HA) and folic acid (FA) decorated nanoparticles to deliver methotrexate and RONS scavenging nanomaterials into the diseased macrophages at RA site. [12,13] Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into the pro-inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Herein, an active targeting nanomedicine based on metal-organic frameworks (MOFs) to re-educate the diseased macrophages for RA therapy is reported. The MOFs are prepared via coordination between tannic acid (TA) and Fe 3+ , and anti-TNF-α siRNA is loaded via a simple sonication process, achieving high loading capacity comparable to cationic vectors. The MOFs show excellent biocompati...

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Metal‐Phenolic Networks Nanoplatform to Mimic Antioxidant Defense System for Broad‐Spectrum Radical Eliminating and Endotoxemia Treatment

Cited by 81 publications

References 79 publications

Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation

Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy

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