Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Abstract

Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inflammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study offers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants.

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

“…Glutathione is the primary free antioxidant peptide in cells and is used as an electron donor by several antioxidant enzymes. To obtain an effective and practical antioxidant, Ma and colleagues 78 co-assembled Myr, Zn 2+ , and GSH into Myr–Zn 2+ –GSH (MZG) nanoparticles, which demonstrated high water solubility, good bioavailability and biocompatibility, and a stable antioxidant effect. The main driving force for the formation of MZG was coordination interactions, which are the strongest non-covalent interactions, thus ensuring better stability under physiological conditions and stable antioxidant performance without affecting the clearance of ROS by Myr and GSH.…”

Antihyperlipidemic activity of myricetin

“…Moreover, myricetin has a unique chemical structure. The combined contribution of hydroxyl groups at the 3 and 5 positions and three continuous hydroxyl groups at positions 3 0 , 4 0 , and 5 0 can increase the antioxidant effectiveness of myricetin (Ma et al, 2022). T-SOD and GSH-Px are the major antioxidant enzymes that play a pivotal role in scavenging oxygen free radicals that protect the pancreatic tissue against oxidative stress injury.…”

Evaluation of Advanced Glycation End Products, Oxidative Stress and Antioxidants and their Relationship in Diabetic patients

“…Free radicals and oxidative stress (OS) play a major role in the development and progression of diabetic complications (Bala et al, 2021, Moridi et al, 2015, Deng et al, 2021, Tsai et al, 2021. Oxidative stress (OS), a pathological condition, is associated with the overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which reduces the scavenging capacity of antioxidant systems (Ma et al, 2022, El-Masry and Mahmoud, 2021, Parcheta et al, 2021, Hajam et al, 2022. Enhanced oxidation of lipids, proteins, and DNA, which has been observed in DM patients from the early stages, may result in organ damage (Asgharpour andAlirezaei, 2021, Michalak, 2022).…”