Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Li, Qiao; Lianghao, Yuan; Shijie, Gao; Zhiyi, Wang; Yuanting, Tang; Cong, Chen; Chun-Qin, Zhao; Xianjun, Fu

doi:10.1039/d3bm01451g

Biomater. Sci.

2024

DOI: 10.1039/d3bm01451g

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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Qiao Li,

Yuan Lianghao,

Gao Shijie

et al.

Abstract: Traditional Chinese medicine (TCM) are combinations of raw herbs and herbal extracts with a plethora of documented beneficial bioactivities, which have unique advantages in anti-tumor, and many of the major...

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Cited by 3 publications

References 215 publications

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Enhancement of the water solubility of curcuminoids by micelle formulations with ginsenosides to improve antioxidant activity, suppress nitric oxide release, and reduce lipid accumulation

Kim,

Gil Kang,

Seong

et al. 2024

Journal of Functional Foods

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Enhancement of the water solubility of curcuminoids by micelle formulations with ginsenosides to improve antioxidant activity, suppress nitric oxide release, and reduce lipid accumulation

Kim,

Gil Kang,

Seong

et al. 2024

Journal of Functional Foods

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Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing

Wu,

Zang,

Qiu

et al. 2024

Molecules

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Carrier-free self-assembly has gradually shifted the focus of research on natural products, which effectively improve the bioavailability and the drug-loading rate. However, in spite of the existing studies, the development of self-assembled natural phytochemicals that possess pharmacological effects still has scope for further exploration and enhancement. Herein, a nano-delivery system was fabricated through the direct self-assembly of Rhein and Matrine and was identified as a self-assembled Rhein-Matrine nanoparticles (RM NPs). The morphology of RM NPs was characterized by TEM. The molecular mechanisms of self-assembly were explored using FT-IR, 1H NMR, and molecular dynamics simulation analysis. Gelatin methacryloyl (GelMA) hydrogel was used as a drug carrier for controlled release and targeted delivery of RM NPs. The potential wound repair properties of RM NPs were evaluated on a skin wound-healing model. TEM and dynamic light scattering study demonstrated that the RM NPs were close to spherical, and the average size was approximately 75 nm. 1H NMR of RM NPs demonstrated strong and weak changes in the interaction energies during self-assembly. Further molecular dynamics simulation analysis predicted the self-assembly behavior. An in vivo skin wound-healing model demonstrated that RM NPs present better protection effect against skin damages. Taken together, RM NPs are a new self-assembly system; this may provide new directions for natural product applications.

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Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Zhai,

Niu,

et al. 2024

Molecules

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Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering a rich source of bioactive compounds with therapeutic potential. However, the clinical application of TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, the development of advanced polymer nanocarriers has emerged as a promising strategy for the delivery of TCMs. This review focuses on the introduction of common active ingredients from TCMs and the recent advancements in the design and application of polymer nanocarriers for enhancing the efficacy and safety of TCMs. We begin by discussing the unique properties of TCMs and the inherent challenges associated with their delivery. We then delve into the types of polymeric nanocarriers, including polymer micelles, polymer vesicles, polymer hydrogels, and polymer drug conjugates, highlighting their application in the delivery of active ingredients from TCMs. The main body of the review presents a comprehensive analysis of the state-of-the-art nanocarrier systems and introduces the impact of these nanocarriers on the solubility, stability, and bioavailability of TCM components. On the basis of this, we provide an outlook on the future directions of polymer nanocarriers in TCM delivery. This review underscores the transformative potential of polymer nanocarriers in revolutionizing TCM delivery, offering a pathway to harness the full therapeutic potential of TCMs while ensuring safety and efficacy in a modern medical context.

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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Abstract: Traditional Chinese medicine (TCM) are combinations of raw herbs and herbal extracts with a plethora of documented beneficial bioactivities, which have unique advantages in anti-tumor, and many of the major...

Cited by 3 publications

References 215 publications

Enhancement of the water solubility of curcuminoids by micelle formulations with ginsenosides to improve antioxidant activity, suppress nitric oxide release, and reduce lipid accumulation

Enhancement of the water solubility of curcuminoids by micelle formulations with ginsenosides to improve antioxidant activity, suppress nitric oxide release, and reduce lipid accumulation

Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

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