Metal-imprinted microsphere prepared by surface template polymerization and its application to chromatography

Abstract

A metal ion‐imprinted microsphere was prepared by surface molecular template polymerization. Trimethylolpropane trimethacrylate (TRIM), zinc ions, 1,12‐dodecanediol‐O, O′‐diphenyl phosphonic acid (DDDPA) were used as a crosslinking agent, an imprint molecule, and a functional host molecule. The Zn(II)‐imprinted microspheres, which are spherically well‐defined particles, were prepared by using water‐in‐oil‐in‐water (W/O/W) multiple emulsions. The combination of TRIM and DDDPA serves to align the recognition sites resulting in better template sites produced on the polymer surface. We firstly conducted diagnostic zinc‐ and copper‐ion adsorption tests with the Zn(II)‐imprinted and unimprinted microspheres in order to make an assessment on the effectiveness of the molecular imprinting technique. Further, the metal‐imprinted microspheres were applied to the column operation. The separation and recovery of metals were carried out by an adsorption column packed with the Zn(II)‐imprinted microspheres. This performance was compared to that of commercial chelating resins that possess similar phosphoric functional groups. The Zn(II)‐imprinted polymer shows an extremely high selectivity to the imprinted zinc ions compared to that of the commercial chelating resin. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 689–696, 2000

Preparation of ordered macroporous cinchonine molecularly imprinted polymers and comparative study of their structure and binding properties with traditional bulk molecularly imprinted polymers

“…Such reagents will disturb the formation of the complex of the molecular template and the functional monomer in the molecular imprinting process, thus reducing the specificity of the MIPs. Although Yoshida et al prepared MIPs by using an emulsion surface molecular imprinting technique, the technique seems more favorable for synthesizing covalent MIPs. Besides, this technique needs to use some special reagents such as phenyl phosphonic acid monododecyl ester.…”

Networks for recognition of biomolecules: molecular imprinting and micropatterning poly(ethylene glycol)‐ Containing films

“…The technique has been used in imprinting drugs [53±59], steroids [49, 60±63], nucleic acids and derivatives [64,65], amino acids [38], metal ions [41,66,67], and other molecules [68]. Imprinting of large molecules and proteins have had greater success utilizing two-dimensional surface imprinting rather than within the bulk polymer matrix [35,36].…”

Synthesis and Characteristics of Macroporous Epoxy Resin‐Triethylenetetramine Polymer Modified by Sodium Chloroacetate for Copper Chelation in Aqueous Solution

“…[4][5][6][7] However, an excess of cross-linker sometimes has mass transfer limitations. Although surface molecularly imprinting technology 8 and IIP membranes or ultra-thin films 9 have the potential to overcome mass transfer limitation, the maximum adsorption capacity is not satisfied. Hence, the IIP resins are more suited for quantitative analysis and not for removing environmental contamination.…”