Preparation of ordered macroporous cinchonine molecularly imprinted polymers and comparative study of their structure and binding properties with traditional bulk molecularly imprinted polymers

Abstract

Three-dimensionally ordered macroporous molecularly imprinted polymers (MMIPs) were prepared by a combination of the colloidal crystal template method and the molecular imprinting technique. Traditional bulk molecularly imprinted polymers (BMIPs) were simultaneously synthesized with the same recipe as the MMIPs by using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinker and chloroform as porogen. SEM and Brunauer − Emmett − Teller measurements show that MMIPs have a more regular macroporous structure, a narrower macropore distribution and a greater surface area and porosity compared with BMIPs. The isothermal and kinetic data of both polymers can be fitted with the Freundlich model and a pseudo-second-order equation, respectively. Their specificities to the template molecules are also similar. However, the binding capability, adsorption rate coefficient and internal effective diffusion coefficient of the MMIPs are higher than for the BMIPs when the particle size is above 54 m.

Ordered macroporous quercetin molecularly imprinted polymers: Preparation, characterization, and separation performance

“…Thus the OMMIPs can improve the mass transfer and their recognition sites are more accessible for the substrates. The results agree with the work reported by Liu et al and Zhang et al who found that 3DOM structure can facilitate the diffusion of substrates in the polymers [11,12].…”

“…and Zhang et al. who found that 3DOM structure can facilitate the diffusion of substrates in the polymers .…”

“…435 nm (SD = ±24 nm) were assembled into the colloidal crystal template by a centrifugal method. Centrifugation is an efficient and simple method to prepare large-scale three dimensional (3D) colloidal crystal with a face-centered cubic (fcc) structure [11,20]. Such a template gives rise to a regular 3D spacing between the SiO 2 beads (SEM image see Supporting Information Fig.…”

“…OMMIPs were seldom studied on their application in separation. Interestingly, our previous work indicated that OMMIPs have more excellent rebinding kinetics and higher adsorption capacity compared with the traditional bulk molecularly imprinted polymers (TBMIPs), implying they have potential applications in separation [11,12].…”

Preparation of boronate‐functionalized surface molecularly imprinted polymer microspheres with polydopamine coating for specific recognition and separation of glycoside template

“…However, the Freundlich model is applied for a highly heterogeneous surface, where the system is more heterogeneous as m value is closer to 0. Experimental data (m = 0.66) suggest that, although some degree of heterogeneity is present, a more homogeneous surface can be assumed [23]. Comparatively, the Freundlich model (R 2 , 0.957) gives a much better fitting than the Langmuir model (R 2 , 0.583) for the adsorption onto the SNIMs, indicating the adsorption arises mainly from the heterogeneous nonspecific sites in polymer matrix.…”