Metal-derived nanoparticles in tumor theranostics: Potential and limitations

Kuchur, Oleg A.; Tsymbal, Sergey A.; Shestovskaya, Maria V.; Serov, Nikita; Dukhinova, Marina; Shtil, Alexander А.

doi:10.1016/j.jinorgbio.2020.111117

Cited by 33 publications

(19 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 76 Studies have shown that coated and modified nanoparticles do not lose their original characteristics; however, by modifying the surface of the nanoparticles, the inherent toxicity of the nanoparticles could be reduced, and the biocompatibility of the nanoparticles could be improved at the same time. 77 , 78 The surface functionalization may enable further applications of nano silver in various fields.…”

Section: Promising Methods To Overcome Nano Silver-induced Cytotoxicitymentioning

confidence: 99%

Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang¹,

Wang²,

Yalamarty³

et al. 2022

IJN

View full text Add to dashboard Cite

Nano silver is one of the most widely used engineering nanomaterials with antimicrobial activity against bacteria, fungi, and viruses. However, the widespread application of nano silver preparations in daily life raises concerns about public health. Although several review articles have described the toxicity of nano silver to specific major organs, an updated comprehensive review that clearly and systematically outlines the harmful effects of nano silver is lacking. This review begins with the routes of exposure to nano silver and its distribution in vivo. The toxic reactions are then discussed on three levels, from the organ to the cellular and subcellular levels. This review also provides new insights on adjusting the toxicity of nano silver by changing their size and surface functionalization and their combination with other materials to form a composite formulation. Finally, future development, challenges, and research directions are discussed.

show abstract

Section: Promising Methods To Overcome Nano Silver-induced Cytotoxicitymentioning

confidence: 99%

Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang¹,

Wang²,

Yalamarty³

et al. 2022

IJN

View full text Add to dashboard Cite

show abstract

“…The ideal drug carrier should have special characteristics, such as chemical stability, long half-life, non-toxic or low-toxicity, biodegradability, and high binding capacity [110]. In particular, functionalized metal nanostructures with the ability to encapsulate or bind drugs have more advantages than free drugs and have the advantages of lower drug toxicity, higher targeting efficiency, and longer half-life, which are used to overcome the deficiencies of chemotherapy and photodynamic therapy [109,111].…”

Section: Pdt Combined With Chemotherapymentioning

confidence: 99%

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

et al. 2021

View full text Add to dashboard Cite

Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.

show abstract

“…Metallic NPs have been increasingly highlighted due to their subsequent use as diagnostic and drug vehicle tools in anti-cancer and antibacterial therapy ( Kuchur et al, 2020 ). Researchers have investigated various NPs including iron oxide NPs (Fe 3 O 4) , which have exhibited favourable characteristics such as biocompatibility, low toxicity, and aqueous solubility ( Dadfar et al, 2019 , Xu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line

Alkahtane

Alghamdi

Aljasham

et al. 2022

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Iron oxides have become increasingly popular for their use as a diagnostic and therapeutic tool in oncology. This study aimed to improve pharmacological valuable of Fe 3 O 4 , which may be use to diagnosis colorectal cancers (CRC). Here, we have developed chitosan (CS) coated Fe 3 O 4 through a cost-effective procedure. First, we determined the characterization of OA-C-Fe 3 O 4 by FTIR, UV–Vis spectra, and TEM. Then, we evaluated the photodynamic therapeutic (PDT) activity of OA-C-Fe 3 O 4 in human colorectal carcinoma cell lines (HCT 116). Current results revealed that the light-induced enhanced reactive oxygen species (ROS) activity of the nanoparticles (NPs) and caused cell death via the activity of caspase 9/3. The in vitro magnetic resonance imaging (MRI) experiments in (HCT 116) and human embryonic kidney cells (HEK 293) illustrated that nanohybrid is an effective MRI contrasting agents for the diagnosis of colorectal cancer.

show abstract

Metal-derived nanoparticles in tumor theranostics: Potential and limitations

Cited by 33 publications

References 227 publications

Nano Silver-Induced Toxicity and Associated Mechanisms

Nano Silver-Induced Toxicity and Associated Mechanisms

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line

Contact Info

Product

Resources

About