Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Abstract

Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

“…This process, in turn, facilitates the movement of the complex through cell membranes, enabling its interaction with biological systems and blocking the binding sites for microorganisms. 74 Furthermore, the activities of tellurium (IV) complexes varied towards different strains, influenced by their differing permeability into the cells of those strains. The complexes demonstrated higher antibacterial activity against S. aureus (G + ), S. pyogenes (G + ) compared with the P. aeruginosa (G À ), E. coli (G À ) strain.…”

Polymorphism, mesomorphism and anti-oxidant character of homoleptic bis[(E)-2-(1-((o-ethylphenyl)imino)ethyl)phenolato-κ2-N,O]Ni/Cu(ii) complexes

“…The free radical scavenging activity of the compounds was investigated using the standard DPPH method in methanol. 44,45 The IC 50 values for HL, 1 and 2 were calculated based on % of inhibition vs. concentration of the sample (Fig. 8) and found to be 256.2 mg mL À1 , 335.9 mg mL À1 and 328.16 mg mL À1 , respectively, representing a moderate to medium level of scavenging activity.…”

“…46 The results suggest that the ligands and complexes may act as safe natural antiradicals by scavenging dangerous free radicals generated by the body's regular cellular functions. [44][45][46]…”

Synthesis, Spectral Characterization, Thermal Investigation, Computational Studies, Molecular Docking, and In Vitro Biological Activities of a New Schiff Base Derived from 2-Chloro Benzaldehyde and 3,3′-Dimethyl-[1,1′-biphenyl]-4,4′-diamine

“…Cancer is a hard disease to deal with all over the world for several reasons. One of the biggest problems with getting rid of cancer is that it can become resistant to the drugs used to treat it. − The rate at which cancer responds to cytotoxic drugs is not good enough. Researchers are trying to find a new drug, which has made them think about new agents with less systemic toxicity and better cytotoxicity .…”