Synthesis, Spectral Characterization, Thermal Investigation, Computational Studies, Molecular Docking, and In Vitro Biological Activities of a New Schiff Base Derived from 2-Chloro Benzaldehyde and 3,3′-Dimethyl-[1,1′-biphenyl]-4,4′-diamine

Abstract

The current research involves the synthesis of a new Schiff base through the reaction between 2-chlorobenzaldehyde and 3,3′-dimethyl-[1,1′-biphenyl]-4,4′-diamine by using a natural acid catalyst and a synthesized compound physicochemically characterized by X-ray diffraction, Fourier transform infrared spectroscopy, 1H- and 13C-nuclear magnetic resonance, and liquid chromatography–mass spectrometry. Thermal studies were conducted using thermogravimetric, differential thermal analysis, and differential thermogravimetric curves. These curves were obtained in an inert nitrogen environment from ambient temperature to 1263 K using heating rates of 10, 15, and 20 K·min–1. Using thermocurve data, model-free isoconversional techniques such as Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa, and Friedman are used to determine kinetic parameters. These parameters include activation energy, phonon frequency factor, activation enthalpy, activation entropy, and Gibb’s free energy change. All of the results have been thoroughly investigated. The molecule’s anti-inflammatory and antidiabetic properties were also examined. To learn more about the potential of the Schiff base and how successfully it can suppress the amylase enzyme, a molecular docking experiment was also conducted. For in silico research, the Swiss Absorption, Distribution, Metabolism, Excretion, and Toxicity algorithms were used to calculate the theoretical pharmacokinetic properties, oral bioavailability, toxic effects, and biological activities of the synthesized molecule. Moreover, the cytotoxicity tests against a human lung cancer cell line (A549) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay demonstrated that the synthesized Schiff base exhibited significant anticancer properties.

CuInS2 Nanospheres and Nanowhiskers Enhancing the Electrochemical Properties of Sodium-Ion-Conducting Gel Polymer Electrolytes

“…Over the past few decades, chalcopyrite semiconducting materials as nanofillers have been the subject of extensive research due to their excellent chemical stability and adaptability in the context of energy storage and conversion devices. , Among these, CuInS 2 stands out as a potential candidate due to its nearly 1.5 eV direct energy band gap in the bulk form and nearly 10 5 cm –1 absorbance coefficient. , CuInS 2 has been investigated for a diverse application range including photovoltaic devices, photocatalysis, optoelectronic devices, biological purposes, − etc. In view of the specific applications, CuInS 2 of different morphologies can be fabricated by adopting hydrothermal, solvothermal, or microwave-assisted approach as well as sonochemical, , one-pot synthesis, and ball-milling techniques.…”

High performance photodetectors based on In2S3, In2S1.5Se1.5 and In2Se3 nanostructures

“…16,17 Indium selenide (In 2 Se 3 ) and indium sulphide (In 2 S 3 ) are n-type semiconductors from the III-VIA group and have recently gained popularity due to their exceptional charge transport properties, superior mechanical flexibility, and strong light-matter interactions. [18][19][20][21] In 2 S 3 and In 2 Se 3 have frequently shown different valence-varying structures with different crystalline phases, such as a-In 2 Se 3 , 22 b-In 2 Se 3 , 23 g-In 2 Se 3 , 24 k-In 2 Se 3 , 25 a-In 2 S 3 , b-In 2 S 3 , and g-In 2 S 3 . 26 The materials In 2 S 3 and In 2 Se 3 are currently under discussion as potential possibilities for a wide range of applications including photodetectors, 27 solar cells, 28 photoelectrocatalytic water splitting, 29 gas sensors, 30 electromechanical devices and piezotronic sensors, 31 electronic skin strain sensors, 32 electroresistance switching in ferroresistive memory junctions, 33 etc.…”