Metal-based antibacterial and antifungal sulfonamides: synthesis, characterization, and biological properties

Abstract

Some furanyl-derived sulfonamides and their cobalt(II), copper(II), nickel(II), and zinc(II) complexes have been synthesized. The structural formulae of the complexes have been inferred by using physico-chemical and spectroscopic methods. The new sulfonamides behave as bidentate ligands in complexation with the metals and an octahedral geometry has been suggested for all these complexes. Both the free sulfonamides and their complexes have been screened for their in vitro antibacterial and antifungal activities against a number of bacteria and fungi. In vitro cytotoxic properties of all the compounds were also studied using brine shrimp bioassay.

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

“…Compound (4) showed significant (50%) activity against (d), and (1) and (2) weaker (19 and 24%) against (e) and (a), respectively. Compounds (3) and (5) similarly showed weaker (14-20%) activity against (f), and the same weaker (21%) activity was observed for compound (4) against (b) [55][56][57] .…”

Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

“…The Cu(II) and Ni(II) complexes showed eff values compatible for their square-planer geometry. The Zn(II) complexes exhibited diamagnetic nature 36 . Table 4).…”

Synthesis and characterization of biologically active new Schiff bases containing 3‐functionalized 1,2,4‐triazoles and their zinc(II) complexes: crystal structure of 4‐bromo‐2‐[(E)‐(1H‐1,2,4‐triazol‐3‐ylimino)‐ methyl]phenol

“…The increased lipophilicity then enhances the penetration of the complexes into lipid membranes of the bacterial strains, thus killing more of them. [47,48] In Vitro Antifungal Bioassay…”