Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in

Abstract

ABSTRACT. A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide polymorphisms that we screened were VDR (rs 731236 and rs 1544410), IL-6 (rs 1800795), TCF7L2 (rs 7903146) and TNF-α (rs 1800629). The risk alleles were more frequent in the subjects with type 2 diabetes, except for the TNF-α gene, which was very infrequent in the population; the normal allele occurred at high and similar frequencies in both normal and diabetic individuals.

BsmI polymorphisms in vitamin D receptor gene are associated with diabetic nephropathy in type 2 diabetes in the Han Chinese population

“…We found that in a Chinese Han population, there were alleles B and b at the BsmI site of VDR gene, and the bb genotype accounted for 85%, Bb for 14%, and BB for 1% in the control individuals, consistent with the results found in HapMap of Han Chinese in Beijing (CHB) (bb 87.5%, Bb12.2%) and Zhang et al (Zhang et al, 2005). In the patients with type 2 diabetes, the BB + Bb genotype and allele B frequency were significantly higher than in control individuals, which was consistent with reports by Oh (Oh and Barrett-Connor, 2002), Shi (Shi et al, 2007) and Mukhopadhyaya (Mukhopadhyaya et al, 2010), indicating a correlation between BsmI polymorphism and type 2 diabetes.…”

Host genetic susceptibility to severe dengue infection

“…VDR polymorphism (rs731236 T/C) analysis in a Vietnam study has shown that C allele (author named as t allele) at position 352 was resistant to DSS (p trend analysis) [39]. This correlates with a recent report that VDR T allele was a risk factor of type 2 diabetes with insulin secretion capacity [40]. …”

Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial

“…Considering the high prevalence of vitamin D deficiency in Iranian subjects either with or without diabetes [17,19] and assuming the same prevalence of "non-responders" among the whole population, a huge number of people may not benefit from intake of the usually recommended amount of vitamin D. This individual variability may be, at least in part, explained by vitamin D receptor (VDR) polymorphisms. A significant association between VDR variants and susceptibility to several diseases including cancer [20,21], ulcerative colitis [22], metabolic syndrome [23] and both types of diabetes [24,25] has already been reported. The upcoming results from our study group will soon address the role of VDR genotypes on the variation of outcomes after improvement of vitamin D status in subjects with T2D [12].…”