BsmI polymorphisms in vitamin D receptor gene are associated with diabetic nephropathy in type 2 diabetes in the Han Chinese population

Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

“…The search yielded 67 articles, 7 studies [18, 22–27] contain 1230 DN patients and 1334 diabetic controls were finally recruited into our meta-analysis according to the inclusion and exclusion criteria, all studies reporting the association among ApaI, BsmI, FokI, TaqI of VDR gene polymorphisms and DN susceptibility (Fig. 1).…”

“…There are accumulating evidences to suggest that vitamin D participated in a number of diseases such as DM and DN [14–16]. An increasing number of researches showed that there was a relationship between vitamin D receptor (VDR) gene polymorphisms and DN [17, 18]. Vitamin D exerts its functions by binding to the nuclear or cytosolic VDR, which serves as a transcription activator and is a member of the steroid / thyroid hormone receptor family [17].…”

Effect of 1,25-(OH)2D3 and lipopolysaccharide on mononuclear cell inflammation in type 2 diabetes mellitus and diabetic nephropathy uremia

“…VDR, a member of the nuclear receptor superfamily of proteins, is expressed in most cells (including monocyte/ macrophage) of the immune system. A recent report has suggested that deficiencies in VD and VDR are correlated with the development of chronic inflammatory diseases such as obesity, cardiovascular disease, and diabetes, and their complications (Zhang et al, 2012). 1,25-(OH) 2 D 3 mediates VDR in a dose-dependent manner.…”

Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease

“…26 The onset of diabetic nephropathy (DN) is also influenced by VDR BsmI polymorphism as observed in a case-control study including 304 patients with type 2 diabetes mellitus and 100 control individuals belonging to the Han Chinese population. 27 Results from this investigation showed that (1) BsmI BB 1 Bb genotypes and B allele frequency were significantly higher in diabetes with excessive albuminuria than in both the nonalbuminuric patients and controls (individuals with no diabetes); (2) BB 1 Bb genotype and B allele frequency were significantly higher in early onset DN occurring within 1 year than in lateonset DN after 5 years/no DN over the whole follow-up period of 5 years; (3) among patients with DN, albumin excretion rate in 24-hour urine was significantly higher in those having the BB 1 Bb genotypes than in those with bb phenotype; (4) BB 1 Bb genotype was not only correlated with type 2 DN, but also with early onset type 2 DN. 27 The BsmI polymorphism, together with age, diabetes, and calcitriol treatment, strongly influences survival in HD patients.…”

“…27 Results from this investigation showed that (1) BsmI BB 1 Bb genotypes and B allele frequency were significantly higher in diabetes with excessive albuminuria than in both the nonalbuminuric patients and controls (individuals with no diabetes); (2) BB 1 Bb genotype and B allele frequency were significantly higher in early onset DN occurring within 1 year than in lateonset DN after 5 years/no DN over the whole follow-up period of 5 years; (3) among patients with DN, albumin excretion rate in 24-hour urine was significantly higher in those having the BB 1 Bb genotypes than in those with bb phenotype; (4) BB 1 Bb genotype was not only correlated with type 2 DN, but also with early onset type 2 DN. 27 The BsmI polymorphism, together with age, diabetes, and calcitriol treatment, strongly influences survival in HD patients. Patients with the bb genotype were more frequent in the group of survivors than in that of the nonsurvivors (45.7% vs. 21.6%) and had a longer life expectancy than those with the Bb or BB genotype (1,290 vs. 1,152 or 983 days, respectively).…”