Effect of 1,25-(OH)2D3 and lipopolysaccharide on mononuclear cell inflammation in type 2 diabetes mellitus and diabetic nephropathy uremia

Wu, Enoch; Cui, Hailong

doi:10.4238/gmr.15038553

Cited by 4 publications

(3 citation statements)

References 18 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Yuan et al found that a combination therapy of vitamin D and tacrolimus can effectively alleviate renal tissue damage in IgAN rats . Besides, a large body of evidence demonstrates that VDR agonists can effectively attenuate the progression of DN . In addition, vitamin D and its analog therapy could improve kidney and cardiovascular functions in patients with CKD .…”

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Wan

Yang

et al. 2018

Ther Apher Dial

View full text Add to dashboard Cite

Our pooled analysis aimed to assess the impact of vitamin D receptor (VDR) gene polymorphism on chronic renal failure (CRF) susceptibility. Relevant studies were searched from multiple databases, then pooled-analyses were performed using Stata software. Eighteen studies involving 2512 CRF patients and 3630 healthy controls were included. Pooled analysis showed that VDR ApaI and TaqI gene polymorphism were not associated with CRF susceptibility either in Asian or in Caucasians populations, and VDR BsmI and FokI gene polymorphism were not associated with CRF susceptibility in overall populations. The subgroup analysis showed that VDR BsmI gene polymorphism was associated with CRF susceptibility in Chinese under the Allele model (OR = 0.76, 95% CI: 0.59-0.97, P = 0.029). In Spanish individuals, VDR BsmI gene polymorphism was associated with CRF: Recessive model (BB vs. Bb + bb): OR = 1.60, 95% CI: 1.09-2.35, P = 0.016; Additive model (BB + bb vs. Bb): OR = 1.60, 95% CI: 1.21-2.12, P = 0.001). In addition, in the Asian subgroup, VDR FokI gene polymorphism was associated with CRF risk: Allele model (F vs. f): OR = 0.31, 95% CI: 0.16-0.59, P = 0.000; Dominant model (FF + Ff vs. ff): OR = 0.12, 95% CI: 0.03-0.59, P = 0.009 and Recessive model (FF vs. Ff + ff): OR = 0.32, 95% CI: 0.13-0.75, P = 0.009. This pooled analysis showed that VDR BsmI gene polymorphism was associated with CRF risk in the Chinese and Spanish individuals, and, VDR FokI gene polymorphism was associated with CRF risk in Asian subjects. But VDR ApaI and TaqI gene polymorphism were not associated with CRF risk either in Asian or in Caucasian individuals.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Wan

Yang

et al. 2018

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

“…Vitamin D appears to be able to modulate the immune response by down-regulation of HLA-DR expression [119]. Another study demonstrated that vitamin D exerts anti-inflammatory effects in diabetic nephropathy via TLR/NF-κB signaling pathways [120]. Observations in a small patient number with vitamin D deficiency suggested that repletion might influence monocyte activity as serum levels of inflammatory leucocyte-derived cytokines, such as IL-8, IL-6, and TNF-α, were decreased [121].…”

Section: Further Factors That Influence Monocyte Activationmentioning

confidence: 99%

Monocytes in Uremia

Girndt

Trojanowicz

Ulrich

2020

Toxins

View full text Add to dashboard Cite

Monocytes play an important role in both innate immunity and antigen presentation for specific cellular immune defense. In patients with chronic renal failure, as well as those treated with maintenance hemodialysis, these cells are largely dysregulated. There is a large body of literature on monocyte alterations in such patients. However, most of the publications report on small series, there is a vast spectrum of different methods and the heterogeneity of the data prevents any meta-analytic approach. Thus, a narrative review was performed to describe the current knowledge. Monocytes from patients with chronic renal failure differ from those of healthy individuals in the pattern of surface molecule expression, cytokine and mediator production, and function. If these findings can be summarized at all, they might be subsumed as showing chronic inflammation in resting cells together with limited activation upon immunologic challenge. The picture is complicated by the fact that monocytes fall into morphologically and functionally different populations and population shifts interact heavily with dysregulation of the individual cells. Severe complications of chronic renal failure such as impaired immune defense, inflammation, and atherosclerosis can be related to several aspects of monocyte dysfunction. Therefore, this review aims to provide an overview about the impairment and activation of monocytes by uremia and the resulting clinical consequences for renal failure patients.

show abstract

“…In line with these observations, Wu et al . reported that 1,25(OH) 2 D 3 can reverse LPS-induced pro-inflammatory cytokines in mononuclear cells from type 2 diabetic and uremia patients [ 110 ]. Yang et al .…”

Section: Renoprotective Mechanisms Of Vdrmentioning

confidence: 99%

Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

Yang

Wang

et al. 2018

CMC

View full text Add to dashboard Cite

Background: Kidney disease is a serious problem that adversely affects human health, but critical knowledge is lacking on how to effectively treat established chronic kidney disease. Mounting evidence from animal and clinical studies has suggested that Vitamin D Re-ceptor (VDR) activation has beneficial effects on various renal diseases.Methods: A structured search of published research literature regarding VDR structure and function, VDR in various renal diseases (e.g., IgA nephropathy, idiopathic nephrotic syndrome, renal cell carcinoma, diabetic nephropathy, lupus nephritis) and therapies targeting VDR was performed for several databases.Result: Included in this study are the results from 177 published research articles. Evidence from these papers indicates that VDR activation is involved in the protection against renal inju-ry in kidney diseases by a variety of mechanisms, including suppression of RAS activation, an-ti-inflammation, inhibiting renal fibrogenesis, restoring mitochondrial function, suppression of autoimmunity and renal cell apoptosis.Conclusion: VDR offers an attractive druggable target for renal diseases. Increasing our under-standing of VDR in the kidney is a fertile area of research and may provide effective weapons in the fight against kidney diseases

show abstract

Effect of 1,25-(OH)2D3 and lipopolysaccharide on mononuclear cell inflammation in type 2 diabetes mellitus and diabetic nephropathy uremia

Cited by 4 publications

References 18 publications

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Monocytes in Uremia

Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

Contact Info

Product

Resources

About