Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Li, Li; Wan, Qingsong; Yang, Shikun; Zhao, Shourong

doi:10.1111/1744-9987.12714

Cited by 14 publications

(7 citation statements)

References 46 publications

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“…VDR FokI SNP is closely associated with renal dysfunction in IgAN patients, which also supported the concept that genetic factors play an important role in IgAN renal function and progression. A previous study has shown that VDR FokI polymorphism is associated with risk of CRF in Asians (Li et al, 2018), which is also supported by our findings.…”

Section: Discussionsupporting

confidence: 92%

Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy

Pan

Tan

et al. 2019

PeerJ

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Background Studies have shown that the occurrence and development of IgA nephropathy (IgAN) are genetically susceptible, but the relationship between vitamin D receptor (VDR) gene polymorphisms and renal function in IgAN patients is unclear. Methods We investigated the relationship between VDR FokI (rs2228570) single nucleotide polymorphism (SNP) and renal function and related clinicopathologic parameters in IgAN patients. Clinical and pathological data of 282 IgAN patients treated at the First Affiliated Hospital of Guangxi Medical University were collected, and FokI genotypes were determined by PCR and direct sequencing. Patients were divided into the renal dysfunction group and normal renal function (control) group by estimated glomerular filtration rate (eGFR) and serum creatinine level. Results Frequencies of TT genotype and T allele in the renal dysfunction group were higher than those of the control group. Blood urea nitrogen, serum phosphorus (P), proportions of mesangial cell proliferation, interstitial fibrosis/tubular atrophy and crescents in T allele carriers were higher than those in non-T allele carriers, while eGFR and 25-Hydroxyvitamin D3 were lower in T allele carriers than non-T allele carriers. Multiple linear regression analysis showed that eGFR was affected by FokI genotypes in IgAN patients. Logistics regression analysis showed that middle and elderly age, elevated P, intact parathyroid hormone and TT genotype were independent risk factors for renal dysfunction in IgAN patients; the odds ratio of carrying the TT genotype was as high as 84.77 (P < 0.05 for all). Conclusions IgA nephropathy patients carrying the VDR FokI TT genotype have an increased risk of renal dysfunction. VDR FokI SNP is closely related to renal function, calcium-phosphate metabolism, and related pathological damage in IgAN patients.

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Section: Discussionsupporting

confidence: 92%

Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy

Pan

Tan

et al. 2019

PeerJ

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“…Current data is also in harmony with the theoretical perspectives of Li Li et al, who mentioned that there was no association between FokI VDR gene polymorphism and chronic renal failure in the dialyzed ESRD patients without T2DM of Caucasian populations [20] . That may be due to the risk of chronic renal failure and ESRD increased in the presence of other chronic diseases such as diabetes mellitus (DM) which increased in the case of single nucleotide polymorphism of FokI VDR causing a change in the length of amino acid sequence producing FokI single nucleotide polymorphism and increasing (f) allele.…”

Section: Discussionsupporting

confidence: 77%

Association Study of Vitamin D Deficiency and its receptor Gene Polymorphism in Diabetic Nephropathy

Elhuseiny,

Ezz,

Mohamed

et al. 2024

Egyptian Journal of Pure and Applied Science

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Vitamin D deficiency and polymorphisms in the vitamin D receptor (VDR) gene have been linked to type 2 diabetes (T2DM) and diabetic nephropathy. This study aimed to evaluate the prevalence of vitamin D deficiency and VDR gene polymorphisms (ApaI rs7975232 and FokI rs2228570) in Egyptian patients with T2DM and to determine their associations with the development of diabetic nephropathy. A total of 75 patients with end-stage renal disease (ESRD), 75 patients with T2DM, 75 patients with diabetic nephropathy, and 30 normal controls were included in the study. Biochemical analysis was performed, including measurements of 25-hydroxy vitamin D [25(OH)D], fasting blood sugar (FBS), postprandial sugar (PPS), homeostatic model assessment of insulin resistance (HOMA-IR), fasting insulin, glycated hemoglobin (HbA1c), blood urea, serum creatinine, estimated glomerular filtration rate (eGFR), albumin-creatinine ratio, total calcium, phosphorus, and lipid profile. VDR gene polymorphisms were detected using the PCR-RFLP technique. The results showed significantly lower levels of vitamin D in patients with T2DM (31.9 ± 8.1 ng/ml) and diabetic nephropathy (10.8 ± 8.1 ng/ml) compared to control subjects (44.9 ± 20.7 ng/ml) (P < 0.001). Vitamin D insufficiency was more prevalent in patients with T2DM and diabetic nephropathy. There was a significant increase in the frequencies of the (ff) and (AA) genotypes and the (f) and (A) alleles in the T2DM group. In conclusion, our study found a high prevalence of vitamin D deficiency in Egyptian patients with T2DM and diabetic nephropathy. There were also significant differences in the distribution of FokI genotypes and alleles between patients with T2DM and controls, suggesting a potential risk factor for Egyptian patients with T2DM. However, the (a) allele of the ApaI genotype appeared to have a protective effect in Egyptian patients.

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“…The most common forms of vitamin D receptor (VDR) gene single‐nucleotide polymorphisms are ApaI , BsmI , FokI , and TaqI . It has been shown that vitamin D receptor BsmI and FokI gene polymorphisms are statistically associated with CKD risk . Therefore, the assay levels and VDR polymorphisms may also affect the results in our meta‐analysis.…”

Section: Discussionmentioning

confidence: 98%

Effect of Vitamin D Supplementation on Vascular Function and Inflammation in Patients with Chronic Kidney Disease: A Controversial Issue

2019

Ther Apher Dial

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Vitamin D deficiency is common in patients with CKD and is associated with vascular dysfunction and inflammation. In recent years, some randomized controlled trials have revealed the effect of vitamin D supplementation on vascular function and inflammation in CKD patients, but the results are inconsistent. Thus, in light of the controversy, we performed a systematic review and meta-analysis of the effect of vitamin D in patients with CKD. We searched the literature in multiple databases for clinical trials from the date of inception to December 2018. The standardized mean difference (SMD) effect size was pooled using fixed and random effects models. A total of 10 randomized controlled trials involving 579 patients were included in the meta-analysis; among these, 313 patients were treated with vitamin D, and the control group included 266 who received a placebo. This meta-analysis revealed no statistical significance in the levels of flow-mediated dilatation (SMD, 0.94; 95% CI, −0.33 to 2.21; P = 0.15); pulse wave velocity (SMD, −0.13; 95% CI, −0.38 to 0.13; P = 0.33); systolic BP (SMD, −0.04; 95% CI, −0.29 to 0.22; P = 0.77); diastolic BP (SMD, 0.01; 95% CI, −0.26 to 0.27; P = 0.97); and CRP (SMD, −0.09; 95% CI, −0.44 to 0.26; P = 0.61) between the vitamin D group and controls for patients with CKD. Short-term intervention with vitamin D was not associated with improvements in vascular function and inflammation, as measured by flow-mediated dilatation, pulse wave velocity, systolic BP, diastolic BP and CRP. This suggested that there is insufficient evidence to conclude the benefit of vitamin D supplementation on vascular function and inflammation in CKD patients.

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Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Cited by 14 publications

References 46 publications

Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy

Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy

Association Study of Vitamin D Deficiency and its receptor Gene Polymorphism in Diabetic Nephropathy

Effect of Vitamin D Supplementation on Vascular Function and Inflammation in Patients with Chronic Kidney Disease: A Controversial Issue

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