Host genetic susceptibility to severe dengue infection

Abstract

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.

Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication

“…DHF is clinically characterized by bleeding and plasma leak, and a severe DHF leads to hypovolemia and even circulatory collapse in the affected patient, which is known as dengue shock syndrome (DSS) [1, 2]. Well-documented risk factors for DHF include secondary infection caused by a DENV serotype which differs from that responsible for the prior dengue episode [3, 4], the genetic predilection for causing hemorrhage of the culprit DENV [5, 6], the genetic predisposing for hemorrhage of the dengue patient [7], the aging of the host [8, 9], and diabetes mellitus (DM) [10–13]. DM is a multifaceted disease that implicates metabolic derangements and immune dysfunction [14].…”

Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection

“…The observation that African ancestry was associated with protection against DHF and DSS in Cuba and Brazil indicates a major role for host genetic variations in determining the clinical outcome of DENV infection [3,4]. The association of variants of human leukocyte antigen class I and class II genes, tumor necrosis factor (TNF)-a, CD209, FcGRIIA, vitamin D receptor (VDR), transporters associated with antigen presentation (TAP) and JAK1 genes with disease severity in dengue have been reported [5].…”

Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population

“…Las variantes rs1800750, rs2069843 y rs2069705 se tipificaron mediante ensayos de reacción en cadena de la polimerasa combinados con polimorfismos en la longitud de fragmentos de restricción (PCR-RFLP). Los genes candidatos se seleccionaron con base en los estudios de fisiopatología del dengue citados en la introducción (11)(12)(13)(14)(15)(16)(17)(18)(20)(21)(22)24,26). Los cebadores utilizados están detallados en el cuadro suplementario 1.…”

“…La expresión de los genes TNFA, IL6 e IFNG fue elevada en casos de dengue hemorrágico, pero este grupo de transcriptos no siempre se expresaron en el mismo grupo étnico (16,17).…”