Metachronous benign ovarian tumors are not uncommon in children

Taskinen, Seppo; Urtane, Alda; Fagerholm, Riitta; Lohi, Jouko; Taskinen, Mervi

doi:10.1016/j.jpedsurg.2013.09.019

Cited by 57 publications

(57 citation statements)

References 12 publications

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“…Contralateral metachronous teratomas developed with a delay of 11 to 84 months in 5/95 patients with ovarian teratomas . This is in line with a 66% ± 26% risk of metachronous teratomas published within 10 years . This highlights the need for a yearly ultrasound follow‐up during reproductive period, and ovary preserving surgery in the case of metachronous tumor.…”

supporting

confidence: 68%

Pediatric teratomas: Still fascinating

Frappaz

2015

Pediatric Blood & Cancer

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supporting

confidence: 68%

Pediatric teratomas: Still fascinating

Frappaz

2015

Pediatric Blood & Cancer

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“…Although this percentage is low, this possibility is worth bearing in mind when scheduling patient follow‐up. The risk of bilaterality is already known and ranges from 10 to 23% in women of all ages . In our sample, the timing of the diagnosis of contralateral tumors ranged between 11 and 84 months, but the interval could be even longer.…”

Section: Discussionmentioning

confidence: 83%

Mature and immature teratoma: A report from the second Italian pediatric study

Terenziani

D’Angelo

Inserra

et al. 2015

Pediatric Blood & Cancer

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Background Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the first Italian study, we collected cases of teratoma, alongside the protocol for malignant germ cell tumors. Procedure Patients with teratoma were collected from 2004 to 2014. Teratomas were classified according to the WHO classifications, as mature and immature. Patients with pathological aFP and/or bHCG, and those with a malignant germ cell component were not included. Results The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a second metachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event‐free, relapse‐free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions Teratomas show a good prognosis, especially the mature ones: surgery and follow‐up remain the standard approach. Incomplete surgery in immature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses. Pediatr Blood Cancer 2015;62:1202–1208. © 2015 Wiley Periodicals, Inc.

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“…However, four girls with mature teratoma were later diagnosed with a new benign tumor in the contralateral ovary. These cases have been published previously and one of these girls has since had a second recurrence in the remaining ovary.…”

Section: Resultsmentioning

confidence: 90%

“…More studies are needed to establish the characteristics of patients with malignant germ cell tumors that appear cured with only surgery. However, four of the girls in our study with a benign tumor developed a contralateral benign neoplasm . Hence, we feel that pediatric patients undergoing operations for mature teratoma need follow up up to a potential child‐bearing age to detect early possible contralateral recurrence in order to make ovary‐preserving surgery possible.…”

Section: Discussionmentioning

confidence: 86%