Pediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome

Taskinen, Seppo; Fagerholm, Riitta; Lohi, Jouko; Taskinen, Mervi

doi:10.1111/aogs.12598

Cited by 53 publications

(46 citation statements)

References 17 publications

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“…These tumors were found in 3 women, 2 of them were pregnant. Similar morphological features have been described by Massicot et al [18], investigating SMT in 23 girls with mean age of 11.5 years. The investigators found papillary structures inside cystadenomas in only 4 girls in puberty, suggesting the need for hormonal stimulation.…”

Section: Discussionsupporting

confidence: 85%

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

Shamarakova¹,

Adamyan²,

Asaturova³

et al. 2018

Akusherstvo i ginekologiia

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Endometriosis affects up to 15% of reproductive-aged women. Consideration of this nosological entity in a new aspect is impelled by the evidence that 0.5-1% of cases are complicated by endometriosis-associated ovarian neoplasms represented mainly by the endometrioid and clear-cell subtypes of tumors. This category also includes seromucinous ovarian tumors (SMOTs). Objective. To investigate the morphological and immunohistochemical (IHC) features of SMOTs in reproductiveaged women, including pregnant ones. Subjects and methods. Ovarian tumor samples from 15 patients who had been operated on in 2012-2016 were analyzed comprehensively at the National Medical Research Center of Obstetrics, Gynecology, and Perinatology: IHC examination was conducted using the biomarkers of estrogen and progesterone receptors and Ki-67. Results. Borderline SMOTs were characterized by papillary growths on the inner surface (in one case) and on the outer surface, with an adhesive process with the serous surface of the corpus uteri (FIGO Stage 1c), and mixed epithelial structures; leukocyte infiltration was observed in four cases. The epithelium of seromucinous carcinoma (n = 1) was similar to that of serous, endocervical, and endometrial types at the same time. All the samples exhibited low Ki-67 expression and high positive receptor immunoreactivity. Endometriosis diagnosed in nine women was accompanied by benign seromucinous cystadenomas (n = 4), borderline tumors (n = 4), and carcinoma (n = 1). Conclusion. Most of the examined SMOTs showed the areas, covered with the endometrioid epithelium, with adjacent endometrial stroma, which indicated the development of carcinoma in the presence of endometrioid cyst. The revealed facts suggest that endometriosis plays an etiological role in developing SMOTs. When detected, most neoplasms are localized (limited to ovarian tissue, FIGO stage 1a) and characterized by a favorable prognosis as a whole.

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Section: Discussionsupporting

confidence: 85%

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

Shamarakova¹,

Adamyan²,

Asaturova³

et al. 2018

Akusherstvo i ginekologiia

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“…In a retrospective review by Taskinen et al, 45 patients who underwent surgery for an ovarian neoplasm at a single institution were evaluated. This report provided a descriptive look at tumor marker testing and results by pathology [1]. Unfortunately, the small cohort made it difficult to identify any significant correlation, but the authors reported that AFP and CA 125 were most often associated with malignant pathology.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Value of Tumor Markers in Pediatric Ovarian Neoplasms

Lawrence

Fallat

Hewitt

et al. 2020

Journal of Pediatric Surgery

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Purpose: The purpose of this study was to determine the diagnostic accuracy of tumor markers for malignancy in girls with ovarian neoplasms. Methods: A retrospective review of girls 2-21 years who presented for surgical management of an ovarian neoplasm across 10 children's hospitals between 2010 and 2016 was performed. Patients who had at least one concerning feature on imaging and had tumor marker testing were included in the study. Sensitivity, specificity, and negative and positive predictive values (PPV) of tumor markers were calculated. Results: Our cohort included 401 patients; 22.4% had a malignancy. Testing for tumor markers was inconsistent. AFP had high specificity (98%) and low sensitivity (42%) with a PPV of 86%. The sensitivity, specificity, and PPV of beta-hCG was 44%, 76%, and 32%, respectively. LDH had high sensitivity (95%) and Inhibin A and Inhibin B had high specificity (97% and 92%, respectively). Conclusions: Tumor marker testing is helpful in preoperative risk stratification of ovarian neoplasms for malignancy. Given the variety of potential tumor types, no single marker provides enough reliability, and therefore a panel of tumor marker testing is recommended if there is concern for malignancy. Prospective studies may help further elucidate the predictive value of tumor markers in a pediatric ovarian neoplasm population. Type of Study: Retrospective Cohort Review. Level of Evidence: Level III.

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“…However, there are little data on the population-based incidence of ovarian neoplasms in children. 4,6 Previous studies have suggested that about half of the ovarian masses in children are neoplastic. 7,8 In a previous study we found that overall incidence of ovarian neoplasms in 0-15-year-old girls was 2.2/100 000 and the median age at presentation was 13 years.…”

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confidence: 99%

“…7,8 In a previous study we found that overall incidence of ovarian neoplasms in 0-15-year-old girls was 2.2/100 000 and the median age at presentation was 13 years. 6 A Dutch national study has reported an incidence of benign ovarian neoplasms from 0.34 at age of 2 years to 4.38 at age of 12 years per 100 000 girls. 4 The incidence of malignant ovarian neoplasms has been reported to vary with age from 0.04 to 0.85/100 000 girls.…”

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Surgically treated ovarian lesions in preadolescent girls

Ripatti

Taskinen

Koivusalo

et al. 2019

Acta Obstet Gynecol Scand

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Introduction: The purpose of this study was to investigate the epidemiology and characteristics of surgically treated ovarian lesions in preadolescent girls. Material and Methods: This was a retrospective cohort study including all 0-11-year-old girls operated at a single center from 1999 to 2016 for ovarian cysts, neoplasms, or torsions. Patient charts were reviewed for symptoms, preoperative radiological imaging, operative details, and histopathology. Results: We identified 78 girls resulting in a population-based incidence of 4.2/100 000. Infants (n= 44) presented with benign cysts (42/44, 95%, one bilateral), a benign neoplasm (1/44, 2%), and a torsion without other pathology (1/44, 2%). Torsion was found in 25/29 (86%) ovaries with complex and in 3/15 (21%) ovaries with simple cysts in preoperative imaging (p<0.001). Most infants were asymptomatic. Lesions in 1-11-year-old girls (n=34) included benign neoplasms (n=21/34, 62%), malignant neoplasms (n=5/34, 15%), a cyst with torsion (n=1/34, 3%), and torsions without other pathology (n=7/34, 21%). Torsion was more common in benign (17/21, 81%) than in malignant neoplasms (1/5, 20%) (p<0.020). Ovarian diameter did not differ between ovaries with or without torsion (p=0.238), or between benign and malignant neoplasms (p=0.293). The duration of symptoms in lesions with or without torsion was similar. Conclusions: The majority of surgically treated ovarian lesions in preadolescent are benign lesions with torsion. Surgery should be ovary preserving and performed without delay.

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Pediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome

Abstract: Both benign and malignant ovarian tumors are rare in the pediatric population, but the incidence increases with age. High alpha-fetoprotein and CA 125 levels were associated with malignant tumors. The prognosis of the pediatric ovarian tumors seems to be favorable.

Cited by 53 publications

References 17 publications

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

Understanding the Value of Tumor Markers in Pediatric Ovarian Neoplasms

Surgically treated ovarian lesions in preadolescent girls

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