Metabolism, Bioavailability, and Analysis of Dietary Isoflavones

Franke, Adrian A.; Halm, Brunhild M.; Kakazu, Kerry; Li, Xingnan

doi:10.1002/9780470531792.ch10

Cited by 6 publications

(10 citation statements)

References 104 publications

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“…Another cause for discrepancy could be the instrument calibration. Determination of accurate stock solution concentrations needed for instrument calibration is best assured by absorbance readings instead of by weight measurements as large errors can be introduced, particularly when small amounts need to be weighed, when agents are hygroscopic, or only slightly soluble [21]. Therefore, we compiled the available information on extinction coefficients of estrogens (Table 2) and used those consistently for measuring the concentrations of all standards used for calibrating the LCMS instrument.…”

Section: Discussionmentioning

confidence: 99%

Analysis of urinary estrogens, their oxidized metabolites, and other endogenous steroids by benchtop orbitrap LCMS versus traditional quadrupole GCMS

et al. 2011

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Estrogens and other endogenous steroids are known risk markers for cancer. Gas chromatography (GC) with mass spectrometry (MS) has traditionally predominated the analysis of estrogens and other endogenous steroids but liquid chromatography (LC) MS is increasingly favored. Direct comparisons of the two technologies have hitherto not been performed. Steroids were analyzed in urine from 232 premenopausal women in a blinded fashion by benchtop orbitrap LCMS and single quadrupole GCMS. 16 steroidal estrogens including oxidized metabolites could be analyzed by LCMS. LCMS-GCMS Spearman rank correlations of the major estrogens E1, E2, E3, 16α-OHE1, and 2-OHE1 were very high (r=0.72–0.91), and absolute concentrations also agreed (<5% difference for E1, E2, E3, 16α-OHE1). LCMS allowed reinterrogation of acquired data due to orbitrap technology, which permitted post-analysis quantitation of progesterone, cortisol, and cortisone (LCMS-GCMS Spearman rank correlations=0.80–0.84; absolute difference <7%; n=137). GCMS allows the measurement of a wide range of steroids including non-polar analytes that escape the presented LCMS assay. In contrast, orbitrap based LCMS can detect more estrogens, is faster, less costly, allows post data acquisition reinterrogation of certain analytes that had not been targeted a priori, and requires much less urine.

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Section: Discussionmentioning

confidence: 99%

Analysis of urinary estrogens, their oxidized metabolites, and other endogenous steroids by benchtop orbitrap LCMS versus traditional quadrupole GCMS

et al. 2011

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“…It is presumed that hydroxytyrosol penetrates into cell membranes and consequently inhibits the production of leukotriene B4 (LTB4) effectively from endogenous arachidonic acid (Kohyama, Nagata, Fujimoto, & Sekiya, 1997;Tuck & Hayball, 2002). Considerable evidence exists from epidemiological and experimental studies for preventive effects of soy or its isoflavones against chronic diseases including cancer (breast, prostate, colorectal, lung), osteoporosis, cardiovascular disorders and menopausal symptoms, but this has not always been consistent (Franke, Halm, Kakazu, & Li, 2010;Levis, Strickman-Stein, Doerge, & Krischer, 2010;Rimbach et al, 2008). Miyake et al (2005) reported that high intake of soy and isoflavones may be associated with reducing the prevalence of allergic rhinitis.…”

Section: Measurement Unitsmentioning

confidence: 97%

Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review

Shahidi

Ambigaipalan

2015

Journal of Functional Foods

2,177

1,342

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Available online A B S T R A C TThis review reports on the latest research results and applications of phenolic and polyphenolic compounds. Phenolic compounds, ubiquitous in plants, are an essential part of the human diet and are of considerable interest due to their antioxidant properties and potential beneficial health effects. These compounds range structurally from a simple phenolic molecule to complex high-molecular-weight polymers. There is increasing evidence that consumption of a variety of phenolic compounds present in foods may lower the risk of health disorders because of their antioxidant activity. When added to foods, antioxidants control rancidity development, retard the formation of toxic oxidation products, maintain nutritional quality, and extend the shelf-life of products. Due to safety concerns and limitation on the use of synthetic antioxidants, natural antioxidants obtained from edible materials, edible by-products and residual sources have been of increasing interest. This contribution summarizes both the synthetic and natural phenolic antioxidants, emphasizing their mode of action, health effects, degradation products and toxicology. In addition, sources of phenolic antioxidants are discussed in detail.

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“…Exposure to IFLs occurs primarily through the intake of soy products that typically contain a total of 0.01–0.3% IFLs primarily composed of the glycosides of the IFLs daidzein (DE), genistein, and glycitein, which are associated with the protein fraction of soy foods (reviewed in 10, 11). Several lines of evidence support the protective effects of soy intake or IFL exposure against breast cancer in adulthood (7, 9, 12, 13) but particularly when consumption begins at an early age (14-18).…”

Section: Introductionmentioning

confidence: 99%

“…Equol (EQ) is a metabolite formed from intestinal bacteria during digestion by chemically reducing DE (10, 19). It is postulated by some that EQ accounts for many, if not most of the benefits of soy consumption (20).…”

Section: Introductionmentioning

confidence: 99%