Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis

Tang, Ye-Lei; Cheng, Yalan; Ren, Yuping; Yu, Xiaoning; Shentu, Xingchao

doi:10.18240/ijo.2016.07.17

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…We found a significant difference in those suffering from diabetes and hypertension. Previous studies agree with this result [ 22 - 23 ]. It is argued that hypertension is not a direct risk factor for DED, however, antihypertensive medications contribute to the problem [ 22 ].…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies agree with this result [ 22 - 23 ]. It is argued that hypertension is not a direct risk factor for DED, however, antihypertensive medications contribute to the problem [ 22 ]. Encouragingly, not all drugs of hypertension have been linked to DED; some drugs like the angiotensin-converting enzyme inhibitor and receptor blockers have shown to improve the ocular surface [ 24 ].…”

Section: Discussionsupporting

confidence: 89%

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Distribution and Correlation of Ocular Surface Disease Index Scores in a Non-Clinical Population: The Karachi Ocular Surface Disease Study

Hashmani¹,

Mustafa²,

Tariq³

et al. 2020

Cureus

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Introduction There is increasing recognition of dry eye disease (DED) as a significant factor influencing quality of life in seemingly normal individuals. Our goal was to determine the distribution of Ocular Surface Disease Index (OSDI) scores in non-clinical individuals in Karachi, Pakistan. Methods We distributed OSDI questionnaires to subjects aged > 18 years with no active ocular complaint. Examiners were selected from various areas of the city to administer questionnaires to students and the general population. The OSDI score was grouped as per the following: normal (0-12 points), mild (13-22 points), moderate (23-32 points), and severe (33-100 points). Results We surveyed 2433 individuals with a mean age of 30.7±15.6 years. Additionally, the mean OSDI score was 22.4±18.7. To estimate prevalence, we used two OSDI score cutoffs: >13 (64.4%) and >22 points (43.6%). Statistical significance was found using multivariate regression in the following variables: age (p<0.001), contact lens wear (p<0.001), ocular allergies (p<0.001), hypertension (p<0.001), diabetes (p=0.003), and smoking (p=0.047). When graphing mean age against OSDI score, there was a large jump between the third and fourth decades; thereafter, there was a steady increase. Similarly, when plotting smoking, the score was steady until five years and then there was a sharp incline. Conclusion There was a high prevalence of DED in the studied population. Additionally, many systemic and ocular factors were associated with this disease.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Distribution and Correlation of Ocular Surface Disease Index Scores in a Non-Clinical Population: The Karachi Ocular Surface Disease Study

Hashmani¹,

Mustafa²,

Tariq³

et al. 2020

Cureus

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“…In addition, the OSDI scores were higher for the study group compared to those recorded for the control group, but both indicated dry eye conditions. Several reports, including a case control and several cross-sectional studies, were conducted to test the link between BMI and dry eye syndrome based on dry eye questionnaires 37–41. Those studies showed that there was no association between dry eye symptoms and increased BMI.…”

Section: Discussionmentioning

confidence: 99%

<p>Assessment of tear film in subjects with a high body mass index</p>

Alanazi¹

2019

OPTO

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Purpose The aim of the study was to assess the tear film in subjects with a high body mass index (BMI). Methods Twenty male subjects aged 23–42 years (mean ± standard deviation =31.3±5.7 years) with a high BMI [median (interquartile range) =31.8 (5.2) kg/m 2 ] were recruited. An age-matched control group of twenty male subjects aged 22–38 years with a normal BMI [20.5 (2.8) kg/m 2 ] also participated in the study. Results There were significant (Kolmogorov-Smirnov test; P <0.05) differences in the BMI, non-invasive tear break-up time (NITBUT), and tear ferning (TF) scores between the study and control groups. There were some differences in the ocular surface disease index (OSDI), tear meniscus height (TMH), and phenol red thread (PRT) scores between the study and control groups, but these differences were not significant (Kolmogorov-Smirnov test; P >0.05). For the study group, the NITBUT and TF tests mean scores showed a dry eye condition (8.5±2.8 s and 2.0±1.1, respectively). However, these two tests showed a normal eye condition within the control group (14.7±2.8 s and 0.7±0.6, respectively). The TMH score had strong correlations with the NITBUT ( r =0.711; P =0.001) and PRT scores ( r =0.566; P =0.009) and strong negative correlations with age ( r =–0.503; P =0.024) and the OSDI scores ( r =–0.520; P =0.018). The TF score had a strong correlation with age ( r =0.579; P =0.007) and strong negtive correlations with the scores from the NITBUT ( r =–0.525; P =0.018), TMH ( r =–0.575; P =0.008), and PRT ( r =–0.773; P =0.001) tests. Conclusion The acquired data suggest a high BMI has an effect on the quality of tears. The quality of tears seems to be lower in subjects with a high BMI compared with normal subjects. On the other hand, the tear volume in subjects with a high BMI was just as high and adequate as for normal eye subjects.

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“…Dry eye syndrome is also known as Kerato-Conjunctivitis Sicca is characterized by tear deficiency resulting in damage to cornea and conjunctiva in inter palpebral area reflected mainly as ocular discomfort 1, 2. It has been associated with systemic diseases such as diabetes and hypertension 3, 4. In addition, more stress is emphasized on climatic changes in modern urban life and its negative effect on DES 5 …”

Section: Introductionmentioning

confidence: 99%

“…1 , 2 It has been associated with systemic diseases such as diabetes and hypertension. 3 , 4 In addition, more stress is emphasized on climatic changes in modern urban life and its negative effect on DES. 5 …”

Section: Introductionmentioning

confidence: 99%

Magnitude of diabetes and hypertension among patients with Dry Eye Syndrome at a tertiary hospital of Riyadh, Saudi Arabia – A case series

Houssien

Al-Hawass

2017

Saudi Journal of Ophthalmology

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Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis

Abstract: The present Meta-analysis suggests that all metabolic risk factors except obesity were risk factors for DES.

Cited by 17 publications

References 24 publications

Distribution and Correlation of Ocular Surface Disease Index Scores in a Non-Clinical Population: The Karachi Ocular Surface Disease Study

Distribution and Correlation of Ocular Surface Disease Index Scores in a Non-Clinical Population: The Karachi Ocular Surface Disease Study

<p>Assessment of tear film in subjects with a high body mass index</p>

Magnitude of diabetes and hypertension among patients with Dry Eye Syndrome at a tertiary hospital of Riyadh, Saudi Arabia – A case series

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