Metabolic Syndrome, Its Components, and Diabetes on 5-Year Risk of Recurrent Stroke among Mild-to-Moderate Ischemic Stroke Survivors: A Multiclinic Registry Study

Fang, Xianghua; Liu, Hongjun; Zhang, Xinqing; Zhang, Hongmei; Qin, Xiaoming; Ji, Xunming

doi:10.1016/j.jstrokecerebrovasdis.2015.11.017

Cited by 33 publications

(30 citation statements)

References 31 publications

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“…Our data demonstrated that MIS patients with MetS had higher abdominal obesity, a hypertension, a higher diabetes mellitus ratio or increased blood glucose, higher dyslipidemia ratio, and more frequent SVE than those without MetS. These finding were similarly recognized in previous community studies [ 3 ], [ 4 ]and in a recent study[ 24 ]. However, using a multivariable analysis, the older age, hypertension, increased blood glucose, and higher triglycerides were found to be independent predictors of SVE.…”

Section: Discussionsupporting

confidence: 89%

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

et al. 2016

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BackgroundMinor ischemic stroke (MIS) represents a major global public health problem worldwide due to high incidence. The aim of this study was to investigate whether metabolic syndrome (MetS) is a strong risk for MIS and subsequent vascular events (SVE).MethodsA retrospective cohort study was performed examining symptomatic MIS in a Chinese neurologic outpatient population aged over 25 years without history of stroke. MetS was defined using the International Diabetes Federation criteria. MIS was diagnosed by magnetic resonance imaging-diffusion weighted images or fluid-attenuated inversion recovery.ResultsOf 1361 outpatients, a total of 753 (55.3%) patients were diagnosed with MIS; of them, 80% had a score of 0 using the MIS had a 0 score on the National Institutes of Health Stroke Scale. Among these, 303 (40.2%) individuals with MIS were diagnosed with MetS. Diagnosed of MIS with MetS significantly correlated with abdominal obesity (30.7% v.s 18.0%), hypertension (91.1% v.s 81.6%), increased blood glucose (6.9±2.4 v.s 5.0±0.4), dyslipidemia (78.2% v.s 48.2%), and SVE (50.5% v.s 11.3%) when compared with the controls group. On adjusted analysis, the risk of SVE was also significantly associated with three additional MetS criterion (RR,9.0; 95% CI, 5.677–14.46). Using Cox proportional analysis, risk of SVE in patient with MIS was significantly associated with MetS (RR, 3.3; 95% CI, 1.799–6.210), older age (RR, 1.0; 95% CI, 1.001–1.048), and high blood glucose (RR,1.1; 95%CI, 1.007–1.187).ConclusionsThe MetS is a strong risk factor for MIS, and patients presenting with MIS and MetS are at a high risk of SVE. Further studies are required to determine the improvement of Mets prevention in the reduction of MIS and SVE.

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Section: Discussionsupporting

confidence: 89%

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

et al. 2016

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“…73 On the other hand, a prospective study of 1,087 individuals with mild-tomoderate ischemic stroke, followed for 5 years, showed that the risk of recurrent stroke in the absence of diabetes was similar to those without metabolic syndrome or diabetes. 74 The primary goal of clinical management of metabolic syndrome is to reduce the atherogenic risk factors. At this time, there are no specific guidelines to treat metabolic syndrome per se in stroke survivors; therefore, treatment is aimed at control of individual vascular factors.…”

Section: Metabolic Syndrome and Strokementioning

confidence: 99%

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Tang¹,

Liebeskind²,

Towfighi

2017

Semin Neurol

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The prevalence of obesity, diabetes, and metabolic syndrome has increased globally. These epidemiologic changes are likely responsible for a rise in stroke incidence among young adults, despite declining stroke incidence rates in the elderly. In this review, the authors summarize the current understanding of the epidemiology and pathophysiology of stroke associated with obesity, diabetes, and metabolic syndrome.

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“…Our search focuses on studies examining the association between EAT and MetS risk in adults (34–70 years). [ 11 ] At each step of the selection process, reasons for inclusion/exclusion will be recorded in the PRISMA flowchart. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

“…The epicardial adipose tissue (EAT) can increase in the states of positive energy balance, when the free fatty acids in the blood are converted into triglycerides, and accumulated initially in adipocytes, and with this the concentration of triglycerides in the myocardium, and the disorders of glucose-insulin metabolism, the presence of chronic low-grade inflammation, and increased pro-inflammatory cytokine production by adipocytes are related to the MetS and the EAT dysfunction. [ 7 – 11 ]…”

Section: Introductionmentioning

confidence: 99%

Epicardial adipose tissue and metabolic syndrome

et al. 2018

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Background:The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia, and an increased risk of cardiovascular events. However, there are no systematic analyses, or well-conducted meta-analyses to evaluate the relationship between epicardial adipose tissue (EAT) and (MetS). The aim of this study is to examine this association of EAT with MetS in different ages and sex.Methods:The update systematic review, and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that firstly, examined the association between EAT and MetS, secondly, focus on cohort, case-control, and cross-sectional studies, thirdly, were conducted among in adults aged between 40 and 70 years, fourth, provided sufficient data for calculating ORs or relative risk with a 95% CI, fifth, were published as original articles written in English or other languages, and sixth, have been published until January year 2018 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators.Results:Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. This study will provide a high quality synthesis on the association of EAT and MetS.Conclusion:This systematic review will provide evidence to assess whether there is a strong association of EAT and MetS, and its components.

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Metabolic Syndrome, Its Components, and Diabetes on 5-Year Risk of Recurrent Stroke among Mild-to-Moderate Ischemic Stroke Survivors: A Multiclinic Registry Study

Cited by 33 publications

References 31 publications

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Epicardial adipose tissue and metabolic syndrome

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