Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Wang, Guang-Sheng; Tong, Daoming; Chen, Xiaodong; Yang, Tonghui; Zhou, Yu; Ma, Xiaobo

doi:10.1371/journal.pone.0156243

Cited by 20 publications

(15 citation statements)

References 30 publications

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“…Our study also demonstrated that diabetes associates with NKP compared with non-NKP, but not when compared with the no-KP group. Although we did not differentiate type 1 and type 2 diabetes, it is plausible that the metabolic syndrome underlies the onset and progression of neuropathy and obesity, and its consequences are potential driving adverse factors that propagate altered nerve functioning and injury [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

et al. 2018

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BackgroundNeuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to determine the prevalence of NKP in a community-derived sample with KP and to identify risk factors associated with NKP.MethodsA cross-sectional study was undertaken (n = 9506) in the East Midlands community among responders (aged 40+ years) to a postal questionnaire. Questions included KP severity (numerical rating scale) and type (neuropathic versus nociceptive) using the modified painDETECT questionnaire, as well as age, body mass index (BMI), significant knee injury, widespread pain, pain catastrophising and fatigue. Multinomial regression analysis was used to determine ORs and 95% CIs. Risk factors were categorised into central and peripheral, and proportional risk contribution (PRC) and 95% CI were estimated using ROC.ResultsKP was reported in 28.2% of responders, of whom 13.65% had NKP (i.e., 3.9% of the total population). Women reported more NKP. After adjustment for age, gender, BMI and pain severity, definite NKP showed associations (aOR, 95% CI) with fibromyalgia (4.07, 2.49–6.66), widespread pain (1.93, 1.46–2.53), nodal osteoarthritis (1.80, 1.28–2.53), injury (1.50, 1.12–2.00), pain catastrophising (5.37, 2.93–9.84) and fatigue (5.37, 3.08–9.35) compared with non-NKP participants. Although only central risk factors contributed to NKP (PRC 8%, 95% CI 2.5–12.5 for central vs. PRC 3%, 95% CI −0.25 to 7.5 for peripheral), both central and peripheral risk factors contributed equally to non-NKP (PRC 10%, 95% CI 5–20 for both).ConclusionsNKP appears to be driven largely by central risk factors and may require different prevention/treatment strategies.Trial registrationClinicalTrials.gov, NCT02098070. Registered on 27 March 2014.

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Section: Discussionmentioning

confidence: 99%

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

et al. 2018

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“…72 A retrospective study of 1,361 outpatients with minor stroke showed that individuals with metabolic syndrome had more frequent subsequent vascular events than those without metabolic syndrome. 73 On the other hand, a prospective study of 1,087 individuals with mild-tomoderate ischemic stroke, followed for 5 years, showed that the risk of recurrent stroke in the absence of diabetes was similar to those without metabolic syndrome or diabetes. 74 The primary goal of clinical management of metabolic syndrome is to reduce the atherogenic risk factors.…”

Section: Metabolic Syndrome and Strokementioning

confidence: 99%

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Tang¹,

Liebeskind²,

Towfighi

2017

Semin Neurol

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The prevalence of obesity, diabetes, and metabolic syndrome has increased globally. These epidemiologic changes are likely responsible for a rise in stroke incidence among young adults, despite declining stroke incidence rates in the elderly. In this review, the authors summarize the current understanding of the epidemiology and pathophysiology of stroke associated with obesity, diabetes, and metabolic syndrome.

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“…1,2 The importance of recognizing this syndrome lies in the fact that it is a risk factor for type 2 diabetes mellitus, coronary artery disease, stroke, and cancers and all-cause mortality. [3][4][5][6][7][8][9] The criteria for diagnosing MS have been proposed by various relevant authorities. [10][11][12][13][14] These criteria have both contrasting and similar features [ Table 1].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome among Apparently Healthy Nigerians with the Harmonized Criteria: Prevalence and Concordance with the International Diabetes Federation (IDF) and Third Report of the National Cholesterol Education Programme - Adult Treatment Panel III (NCEP-ATP III) Criteria

Raimi¹,

Odusan²,

Fasanmade³

et al. 2017

JCDR

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Background:The prevalence of metabolic syndrome varies by the definition used and the population studied. In order to make comparison among various studies possible, a new criterion which harmonizes the previous definitions was proposed. This study aims to determine the prevalence of metabolic syndrome with the harmonized criteria, and its concordance with the International Diabetes Federation (IDF), and National Cholesterol Education Programme-Adult Treatment Panel (NCEP-ATP III) criteria. Methods: One hundred and two apparently healthy individuals who participated in health screening were evaluated for metabolic syndrome. The blood pressure and anthropometric parameters were measured according to standard protocol, and fasting plasma glucose and lipid profile were determined. Metabolic syndrome was defined using the Harmonized, IDF and ATP III criteria. The agreement among the three diagnostic criteria was determined with kappa statistics. Results: The prevalence of metabolic syndrome was 4.9%, 3.9% and 4.9% with harmonized, IDF, and NCEP-ATP criteria respectively. Compared to the males, the prevalence was greater in females: Males vs Females (harmonized, 2.2% vs 7.0%; IDF, 2.2% vs 5.3%; NCEP-ATP III, 2.2% vs 7.0%). The commonest risk factor in this population was low HDL occurring in 93.0% and 37.8% of females and males respectively, followed by central obesity (50.9% in females, 13.3% in males with harmonized and IDF criteria; 33.3% in females, 4.4% in males with NCEP-ATP criteria), hypertension (12.5% in females, 18.6% in males) and hyperglycaemia (4.2% in females, 0.0% in males) in that order. None of the participants had elevated Triglyceride. There was a substantial concordance between the harmonized and the IDF (k=0.884) as well as the harmonized and NCEP-ATP III (k=1.000) definitions. Conclusion: The prevalence of metabolic syndrome was low in this population. There was a substantial agreement among the three diagnostic criteria.

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Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Cited by 20 publications

References 30 publications

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Metabolic Syndrome among Apparently Healthy Nigerians with the Harmonized Criteria: Prevalence and Concordance with the International Diabetes Federation (IDF) and Third Report of the National Cholesterol Education Programme - Adult Treatment Panel III (NCEP-ATP III) Criteria

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