Metabolic Syndrome in Overweight and Obese Adolescents: A Comparison of Two Different Diagnostic Criteria

Giannini, Denise Tavares; Kuschnir, Maria Cristina Caetano; Szklo, Moysés

doi:10.1159/000362568

Cited by 23 publications

(17 citation statements)

References 55 publications

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“…Specifically, hepatic steatosis was diagnosed according to characteristic echo patterns, such as diffuse hyperechogenicity of the liver relative to the kidneys, ultrasound beam attenuation, and poor visualisation of intrahepatic structures. The prevalence of MS differs widely in varying studies according to the definition criteria used and the population sample studied3031. To adopt an ethnicity-specific value of waist circumference, the International Diabetes Federation (IDF) has proposed regional definitions of central obesity according to the characteristics of Chinese people.…”

Section: Methodsmentioning

confidence: 99%

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Zhang

Zhao

et al. 2014

Sci Rep

136

100

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High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver disease (NAFLD) in a Chinese population. A total of 840 subjects fulfilled the diagnostic criteria of NAFLD and 331 healthy control participants were enrolled in this cross-sectional study. Fasting serum FFA levels and other clinical and laboratory parameters were measured. NAFLD patients had significantly higher serum FFA levels than controls (P < 0.001). Serum FFA levels were significantly and positively correlated with parameters of MS, inflammation indexes, and markers of hepatocellular damage. Elevated serum FFA levels were found in NAFLD subjects with individual components of MS (obesity, hypertriglyceridaemia, and hyperglycaemia). Stepwise regression showed that serum FFA levels were an independent factor predicting advanced fibrosis (FIB-4 ≥ 1.3) in NAFLD patients. Serum FFA levels correlated with NAFLD and could be used as an indicator for predicting advanced fibrosis in NAFLD patients.

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Section: Methodsmentioning

confidence: 99%

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Zhang

Zhao

et al. 2014

Sci Rep

136

100

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“…In the last decade, MetS has been identified in younger populations (4,(10)(11)(12). This is particularly concerning given the potential earlier manifestations of MetS outcomes, such as type 2 diabetes and CVDs (4,13). The early identification of MetS would permit early preventive actions (14) designed to reduce the burden of type 2 diabetes and CVDs later in life (15).…”

Section: Introductionmentioning

confidence: 99%

Anthropometric measurements as a potential non-invasive alternative for the diagnosis of metabolic syndrome in adolescents

Mastroeni¹,

Mastroeni²,

Ekwaru³

et al. 2019

Archives of Endocrinology and Metabolism

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Objective: To identify which anthropometric measurement would be the best predictor of metabolic syndrome (MetS) in Brazilian adolescents. Subjects and methods: Cross-sectional study conducted on 222 adolescents (15-17 years) from a city in southern Brazil. Anthropometric, physical activity, blood pressure and biochemical parameters were investigated. MetS criteria were transformed into a continuous variable (MetS score). Linear regression analyses were performed to assess the associations of BMI, hip circumference, neck circumference (NC), triceps skinfold, subscapular skinfold and body fat percentage with MetS score. ROC curves were constructed to determine the cutoff for each anthropometric measurement. Results: The prevalence of MetS was 7.2%. Each anthropometric measurement was significantly (p < 0.001) associated with MetS score. After adjusting for potential confounding variables (age, sex, physical activity, and maternal education), the standardized coefficients of NC and body fat percentage appeared to have the strongest association (beta = 0.69 standard deviation) with MetS score. The regression of BMI provided the best model fit (adjusted R 2 = 0.31). BMI predicted MetS with high sensitivity (100.0%) and specificity (86.4%). Conclusions: Our results suggest that BMI and NC are effective screening tools for MetS in adolescents. The early diagnosis of MetS combined with targeted lifestyle interventions in adolescence may help reduce the burden of cardiovascular diseases and diabetes in adulthood.

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“…O aparecimento de doenças metabólicas em jovens nas últimas décadas tem sido cada vez mais evidente [1][2][3][4] . A resistência à insulina compromete o funcionamento adequado de diversos órgãos como fígado, vasos, músculos e tecido adiposo e antecede a intolerância à glicose e a diabetes mellitus tipo 2 5 .…”

Section: Introductionunclassified

Comparação de parâmetros metabólicos em crianças e adolescentes com e sem resistência à insulina

et al. 2018

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O objetivo do estudo foi comparar o comportamento de parâmetros metabólicos, pressão arterial e indicadores de obesidade em crianças e adolescentes com e sem resistência à insulina. Participaram do estudo 60 crianças e adolescentes com excesso de peso (6 a 18 anos) que foram submetidos a medidas antropométricas de massa corporal (MC), estatura e circunferência da cintura (CC), pressão arterial (PA), bioimpedância [gordura relativa (%G) e absoluta (GC)] e coleta sanguínea para determinação das concentrações de glicose, insulina e perfil lipídico (TG, CT, HDL-C, LDL-C). O IMC z-score foi empregado para classificação do estado nutricional e o índice HOMA-RI (>2,5) para resistência à insulina. Os participantes foram divididos em dois grupos, resistentes (RI, n=27) e não resistentes à insulina (NRI, n=33). Independente da idade, crianças e adolescentescom excesso de peso e RI, apresentaram maior MC, CC, IMC, %G e GC (kg), TG e insulina plasmática do que contrapares NRI, que por sua vez, apresentaram valores mais elevados de LDL-C. Os grupos não diferiram para oestado nutricional (IMC z-score) porém, na comparação entre as proporções indesejadas dos componentes metabólicos, apenas três apresentaram alterações com diferenças significativas entre os grupos (CT, LDL-C e TG). Conclui-se que a RI apresenta-se com influência para o desenvolvimento de dislipidemias nessa faixa etária em especial o TG.

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Metabolic Syndrome in Overweight and Obese Adolescents: A Comparison of Two Different Diagnostic Criteria

Cited by 23 publications

References 55 publications

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Anthropometric measurements as a potential non-invasive alternative for the diagnosis of metabolic syndrome in adolescents

Comparação de parâmetros metabólicos em crianças e adolescentes com e sem resistência à insulina

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