Metabolic syndrome components as markers to prognosticate the risk of developing chronic kidney disease: evidence-based study with 6492 individuals

Zomorrodian, Davoud; Rad, Abolfazl Khajavi; Avan, Amir; Ebrahimi, Mahmoud; Nematy, Mohsen; Azarpazhooh, Mahmoud Reza; Emamian, Marzieh; Sadeghzade, Mahsa; Mirhafez, Seyed Reza; Mohammadi, Maryam; Mousavi, Mir F.; Esmaeili, Habibollah; Moohebati, Mohsen; Parizadeh, Mohammad Reza; Ferns, Gordon A.

doi:10.1136/jech-2014-205160

Cited by 44 publications

(33 citation statements)

References 19 publications

(19 reference statements)

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“…Kang et al [5]also demonstrated a 1.53-fold increased ORs for CKD in Koreans with metabolic syndrome based on the general health screening data of 10,253,085 participants. Consistent with these findings, the positive effects of metabolic syndrome on the prevalence of CKD were shown in several studies [6][7][8]31]. In the present study, we showed that metabolic syndrome was significantly associated with a 1.49-fold increased OR for CKD.…”

Section: Metabolic Syndrome and Chronic Kidney Diseasesupporting

confidence: 80%

Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients

Dai

Lu²,

Tang³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients. Methods: A total of 19,848 hypertensive subjects were enrolled in this cross-sectional study. Patients with proteinuria and/or an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m² were considered CKD cases. Results: Hypertensive subjects with CKD had a higher prevalence of hyperuricemia and metabolic syndrome, as well as higher levels of SUA, BMI, waist circumference (WC), SBP, DBP, TG, fasting blood glucose and lower levels of HDL-C. Compared to patients without CKD, the multivariate-adjusted odds ratios [ORs, 95% confidence interval (CI)] for CKD patients were 2.30 (2.02-2.63) for hyperuricemia, 1.21 (1.04-1.41) for abdominal obesity, 1.21 (1.06-1.38) for elevated TG, 1.29 (1.06-1.56) for low HDL-C, 1.54 (1.36-1.75) for elevated fasting glucose, and 1.49 (1.30-1.71) for metabolic syndrome. Increasing SUA levels and number of individual metabolic syndrome components were associated with an increased prevalence of CKD. Compared with patients classified in the lowest SUA categories and with ≤1 metabolic syndrome components, subjects with HUA and 4 metabolic syndrome components had a 5.77-fold increased OR for CKD based on the multivariate-adjusted analysis. Conclusion: Both elevated SUA and metabolic syndrome are associated with an increased prevalence of CKD in hypertensive subjects. Subjects with higher SUA and sum of individual metabolic syndrome components simultaneously have a higher prevalence of CKD.

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Section: Metabolic Syndrome and Chronic Kidney Diseasesupporting

confidence: 80%

Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients

Dai

Lu²,

Tang³

et al. 2016

Kidney Blood Press Res

View full text Add to dashboard Cite

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“…Exclusion criteria included: a known history of infectious diseases, and a family history of stroke, myocardial infarction and diabetes mellitus. Informed consent was obtained from all individuals using approved protocols by the Ethics Committee of the Mashhad University of Medical Sciences …”

Section: Methodsmentioning

confidence: 99%

“…Anthropometric parameters, including height, body weight, Body mass index (BMI) and waist and hip circumference (WC and HC) were measured in all the subjected as previously described, while systolic and diastolic blood pressures were measured by sphygmomanometers . A fasted lipid profile, including total cholesterol (TC), HDL‐C, LDL‐C, TG and fasting blood glucose (FBG) and serum C‐reactive protein (CRP), and uric acid were measured using standard procedure as described previously…”

Section: Methodsmentioning

confidence: 99%

Prevalence of combined and noncombined dyslipidemia in an Iranian population

Darroudi

Saberi‐Karimian

Tayefi

et al. 2018

Clinical Laboratory Analysis

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Background Combination of dyslipidemic phenotypes, including elevated plasma levels of low‐density lipoprotein cholesterol (LDL‐C), elevated plasma triglycerides (TG), and decreased low‐density lipoprotein cholesterol (HDL‐C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD). We investigated the prevalence of combined dyslipidemias and their effects on CVD risk in an Iranian large population. Method A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Anthropometric parameters and biochemical indices were measured in all of the subjects. Different types of combined dyslipidemias including high TG + low HDL‐C, high TG + low HDL‐C + high LDL‐C, low HDL‐C + high LDL‐C, high TG + high LDL‐C, and finally high TG + high LDL‐C + low HDL‐C were considered. Ten‐year CVD risk was calculated using the QRISK2 risk algorithm and adjustments were made as suggested by the Joint British Societies’ (JBS2). Logistic regression analyses were performed to determine the association between different combined dyslipidemias and categorical QRISK. Results A total of 3952 males and 5895 females were included in this current study. Among the included subjects, 83.4% had one form of dyslipidemia, and 16.6% subjects were not dyslipidemic. The mean age was 48.88 ± 7.9 and 47.02 ± 8.54 years for dyslipidemic and nondyslipidemic groups, respectively. The results showed that the frequency of dyslipidemia was 98%, 87.1%, and 90% in subjects with metabolic syndrome, CVD, and diabetes, respectively. Our results suggested that around 15.7% of study population were at 10 years CVD risk (high ≥20) and it was higher in men than women (P < .001). Moreover, risk of CVD was higher in TG↑ & HDL↓ & LDL↑ group than other groups. Conclusion Prevalence of dyslipidemia was 83.4% among Iranian adults. The results showed that individuals with increased plasma TG and LDL‐C, and low HDL‐C levels had the highest 10 years CVD risk compared to other combined dyslipidemic phenotypes.

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“…The study population consisted of 317 patients (57.4% male and 42.6% female, aged 35-78 years) who underwent coronary angiography in the Ghaem Hospital Medical Center, Mashhad, Iran (Zomorrodian et al, 2015). Of the total group of patients, 94 were obese (BMI !…”

Section: Study Populationmentioning

confidence: 99%

Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Mardan-Nik

Pasdar

Jamialahmadi

et al. 2016

Annals of Human Biology

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Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the geneticpolymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/ multivariate analyses were conducted to explore the relationship between the geneticpolymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

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Metabolic syndrome components as markers to prognosticate the risk of developing chronic kidney disease: evidence-based study with 6492 individuals

Cited by 44 publications

References 19 publications

Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients

Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients

Prevalence of combined and noncombined dyslipidemia in an Iranian population

Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

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