Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Abstract

Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the geneticpolymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/ multivariate analyses were conducted to explore the relationship between the geneticpolymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

Differentially expressed genes in the caecal and colonic mucosa of Landrace finishing pigs with high and low food conversion ratios

“…The results of other studies have suggested that the HSP70.2 (heat shock 70 kDa protein 1B) gene might be a candidate gene involved in obesity and type 2 diabetes 38 , 39 . As well as being involved in the immune system and cellular response, these genes are involved in ATP binding, ATPase activity and ATP metabolic processes, which provide the direct energy source for the body.…”

Association of hematocrit with blood pressure and hypertension

“…Hematological factors, including white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), platelet count (PLT), platelet distribution width (PDW) were measured in all the subjects, as described previously …”

Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis

“…Therefore, it is essential to identify more genetic markers that can predict individual NIHL susceptibility potentially. The abnormity of HSP70 have been demonstrated to be related to many diseases, such as obesity [ 19 ], congenital sideroblastic anemia [ 20 ], coronary artery disease [ 21 ] and age-related cataract [ 22 ]. In the research field of NIHL, two studies both suggested an important role of HSP70 in the resistance to NIHL [ 12 , 23 ].…”