Prevalence of combined and noncombined dyslipidemia in an Iranian population

Abstract

Background Combination of dyslipidemic phenotypes, including elevated plasma levels of low‐density lipoprotein cholesterol (LDL‐C), elevated plasma triglycerides (TG), and decreased low‐density lipoprotein cholesterol (HDL‐C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD). We investigated the prevalence of combined dyslipidemias and their effects on CVD risk in an Iranian large population. Method A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Anthropometric parameters and biochemical indices were measured in all of the subjects. Different types of combined dyslipidemias including high TG + low HDL‐C, high TG + low HDL‐C + high LDL‐C, low HDL‐C + high LDL‐C, high TG + high LDL‐C, and finally high TG + high LDL‐C + low HDL‐C were considered. Ten‐year CVD risk was calculated using the QRISK2 risk algorithm and adjustments were made as suggested by the Joint British Societies’ (JBS2). Logistic regression analyses were performed to determine the association between different combined dyslipidemias and categorical QRISK. Results A total of 3952 males and 5895 females were included in this current study. Among the included subjects, 83.4% had one form of dyslipidemia, and 16.6% subjects were not dyslipidemic. The mean age was 48.88 ± 7.9 and 47.02 ± 8.54 years for dyslipidemic and nondyslipidemic groups, respectively. The results showed that the frequency of dyslipidemia was 98%, 87.1%, and 90% in subjects with metabolic syndrome, CVD, and diabetes, respectively. Our results suggested that around 15.7% of study population were at 10 years CVD risk (high ≥20) and it was higher in men than women (P < .001). Moreover, risk of CVD was higher in TG↑ & HDL↓ & LDL↑ group than other groups. Conclusion Prevalence of dyslipidemia was 83.4% among Iranian adults. The results showed that individuals with increased plasma TG and LDL‐C, and low HDL‐C levels had the highest 10 years CVD risk compared to other combined dyslipidemic phenotypes.

Prevalence of dyslipidemia among students of a Yemeni University

“…In our study, the overall prevalence of dyslipidemia (at least one abnormal lipid profile value) was 86.7%. This result is similar to that reported in an Iranian study (83.4%) study 39 . However, our figures are higher than those in other studies.…”

Association between qat chewing and dyslipidaemia among young males

“…For instance, one recent study conducted in KSA reported a 78% prevalence of dyslipidaemia, which is lower than our figures 28 Furthermore, other regional and international studies conducted in Egypt, Turkey, and the United States estimated the prevalence of dyslipidaemia, that is, 63.8%, 78.7%, and 65%, respectively 17 , 20 , 29 . On the contrary, our results are similar to that of an Iranian study that reported a prevalence rate of 83.4% for dyslipidaemia 30 …”

Dyslipidemia and cardiovascular disease risk among the MASHAD study population

“…The prevalence of hypercholesterolemia, hypertriglyceridemia, high levels of LDL-C, and low levels of HDL-C are reported to be 41.6, 46.0, 35.5, and 43.9%, respectively in both sexes in the Iranian population [7]. Darroudi et al have recently reported the prevalence of dyslipidemia among a subsample of Iranian adults to be 83 and 87% in the total population and CVD patients, respectively [8].…”