Metabolic Syndrome and the Risk of Ischemic Stroke

Sarrafzadegan, Nizal; Gharipour, Mojgan; Sadeghi, Masoumeh; Nezafati, Pouya; Talaie, Mohammad; Oveisgharan, Shahram; Nouri, Fatemeh; Khosravi, Alireza

doi:10.1016/j.jstrokecerebrovasdis.2016.09.019

Cited by 46 publications

(29 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stroke incidence rates for those with and without metabolic syndrome were 2.6% and 1.1%, respectively (p ¼ 0.026). 72 A retrospective study of 1,361 outpatients with minor stroke showed that individuals with metabolic syndrome had more frequent subsequent vascular events than those without metabolic syndrome. 73 On the other hand, a prospective study of 1,087 individuals with mild-tomoderate ischemic stroke, followed for 5 years, showed that the risk of recurrent stroke in the absence of diabetes was similar to those without metabolic syndrome or diabetes.…”

Section: Metabolic Syndrome and Strokementioning

confidence: 99%

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Tang¹,

Liebeskind²,

Towfighi

2017

Semin Neurol

View full text Add to dashboard Cite

The prevalence of obesity, diabetes, and metabolic syndrome has increased globally. These epidemiologic changes are likely responsible for a rise in stroke incidence among young adults, despite declining stroke incidence rates in the elderly. In this review, the authors summarize the current understanding of the epidemiology and pathophysiology of stroke associated with obesity, diabetes, and metabolic syndrome.

show abstract

Section: Metabolic Syndrome and Strokementioning

confidence: 99%

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Tang¹,

Liebeskind²,

Towfighi

2017

Semin Neurol

View full text Add to dashboard Cite

show abstract

“…People with MetS are also more likely to have inflammation that could potentially aggravate the incidence of CVD [ 3 , 4 ]. Furthermore, the prevalence of MetS has significantly increased in all regions around the world [ 5 , 6 , 7 , 8 , 9 , 10 ]. A previous study conducted in China found that the prevalence of MetS was 24.5% in 2016 [ 11 ]; in Taiwan, a study using the Nutrition and Health Survey in Taiwan (NAHSIT) showed an increasing trend of MetS from 13.6% to 25.5% from NAHSIT 1993–1996 to NAHSIT 2005–2008, respectively [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Patterns with Components of Metabolic Syndrome and Inflammation among Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan

et al. 2018

View full text Add to dashboard Cite

This study examined the correlation of dietary patterns with components of metabolic syndrome (MetS) and inflammation among middle-aged and older adults with MetS in Taiwan. This cross-sectional study used data from the Mei Jau International Health Management Institution in Taiwan between 2004 and 2013. A total of 26,016 subjects aged 35 years and above were selected for analysis. MetS was defined according to the International Diabetes Federation. Three dietary patterns were identified by principal component analysis. High intake of a meat–instant food dietary pattern (rich in animal protein, saturated fat, sweets, sodium, and food additives) was positively associated with components of MetS and C-reactive protein (CRP), while high intake of a vege–seafood dietary pattern (rich in dietary fiber, vitamins, minerals, and unsaturated fat) or a cereal–dairy dietary pattern (rich in dietary fiber, antioxidants, phytochemicals, complex carbohydrate, prebiotics, and probiotics) was inversely associated with components of MetS and CRP. Our findings suggested that intake of a vege–seafood dietary pattern or a cereal–dairy dietary pattern decreased the risk of developing MetS and inflammation among middle-aged and older adults with MetS.

show abstract

“…However, further analysis indicated that among all medical comorbidities, the risk of ischemic stroke was significantly higher only in patients with hypertension (aHR = 2.09, 95% CI = 1.55–2.82). Evidence has shown that metabolic syndrome and its main definitional components, including high blood pressure and hyperglycemia, are strongly associated with an increased risk of stroke [ 19 , 20 ]. Therefore, early identification and appropriate control of medical comorbidities are key strategies for preventing stroke in patients with NVG.…”

Section: Discussionmentioning

confidence: 99%

Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study

Chang

Lin

et al. 2017

Journal of Ophthalmology

View full text Add to dashboard Cite

Neovascular glaucoma (NVG), caused by ocular ischemia, is a serious ocular disease complicated by intractably increased intraocular pressure. Cerebrovascular accidents are classified into ischemic and hemorrhagic stroke. Based on the similar pathogenic mechanisms of NVG and ischemic stroke, we investigated the relationship between NVG and stroke by using a nationally representative sample. This study included 416 NVG patients and 4160 controls. Medical comorbidities were also evaluated. The cumulative incidence of ischemic stroke was 15.6% higher in the NVG cohort than in the control cohort (p < 0.001); the incidence density rates of stroke were 3.80 and 1.19 per 10,000 person-years in the NVG and control cohorts, respectively. According to the multivariable Cox regression results, the estimated adjusted hazard ratio (aHR) of stroke was 2.07 (95% confidence interval (CI) = 1.41–3.02) for the NVG cohort. Furthermore, the NVG cohort was 2.24-fold more likely to develop ischemic stroke (95% CI = 1.51–3.32). The risk of ischemic stroke was higher in patients with hypertension (aHR = 2.09, 95% CI = 1.55–2.82) and in patients with diabetic retinopathy (aHR = 1.69, 95% CI = 1.05–2.72). Notably, patients with NVG have a higher risk of ischemic stroke, but not hemorrhagic stroke.

show abstract

Metabolic Syndrome and the Risk of Ischemic Stroke

Cited by 46 publications

References 34 publications

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

Association of Dietary Patterns with Components of Metabolic Syndrome and Inflammation among Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan

Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study

Contact Info

Product

Resources

About