Metabolic Syndrome and Its Effects on Cartilage Degeneration vs Regeneration: A Pilot Study Using Osteoarthritis Biomarkers

Onkarappa, Rajath Siddaramanna; Chauhan, Devendra Kumar; Saikia, Biman; Karim, Adil; Kanojia, Ravi Prakash

doi:10.1007/s43465-020-00145-z

Cited by 7 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with our results, a study by Onkarappa et al 30 found that the clinical severity of knee OA was significantly higher in individuals with MetS compared with non-MetS individuals. They also stated that WOMAC scores at presentation and after 6 months were significantly higher in the MetS group.…”

Section: Discussionsupporting

confidence: 93%

“…In concordance with Al Hewala et al, 29 our results showed no significant difference between participants in terms of age. Also, 69.0% of our included participants were smokers, 42.2% were diabetics, 50% were hypertensive, 47.4% were dyslipidemic, 26.7% were obese, and 86% had elevated waist circumference; these findings were in concordance with a study on 41 OA participants by Onkarappa et al, 30 in which 90.24% of the study population had abnormal waist circumference, 43.9% were diabetic, and 41.46% had hypertension. Similarly, a cross-sectional study by Morović-Vergles et al 31 found that among the 352 OA individuals included, 60% had hypertension after adjusting for age and body mass index (BMI).…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt

Samaan

Taha

2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

View full text Add to dashboard Cite

Background: Several studies have linked metabolic syndrome (MetS) to osteoarthritis (OA), but they have not looked into how MetS can affect the health-related quality of life (HRQOL) of OA individuals. Objectives: We aimed to assess the association of MetS and its components, including obesity, hypertension, hyperglycemia, and dyslipidemia, with HRQOL among Egyptians with knee OA. Methods: This cross-sectional study comprised 116 adult Egyptian participants with knee OA. They were divided into 2 groups based on whether or not they had the MetS. All participants were subjected to a thorough medical history taking and a detailed medical examination. The Kellgren and Lawrence (K/L) scale evaluated OA in all individuals using anteroposterior knee radiographs. The Health Assessment Questionnaire-Disability Index (HAQ-DI) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used to assess participants’ HRQOL; their higher scores indicate more disability. Spearman rank and Pearson’s correlation analyses were used to assess the association between variables. Results: Diabetes, hypertension, dyslipidemia, and obesity were significantly associated with the OA + MetS group with a prevalence of 77.6%, 82.8%, 77.6%, and 50.0%, respectively. According to the K/L scale, 70.7% of the OA + MetS group had grade IV knee affection. The HAQ-DI and WOMAC scores were significantly ( P < .001) higher among the OA + MetS individuals compared with the OA individuals. Interleukin (IL)-6 serum levels were also significantly higher in the OA + MetS group ( P = .036) and increased significantly with the more serious radiological damage and functional disability. We found significant positive correlations between HAQ-DI and WOMAC with waist circumference ( P = .004, .001), as well as triglycerides ( P = .006, .008), cholesterol ( P = .041, .048), fasting blood sugar ( P < .001, < .001) and significant negative correlations with high-density lipoprotein levels ( P = .628, .002). Conclusions: Individuals with knee OA with MetS showed more significant radiological damage, severe functional disability, and poor HRQOL. They also had higher levels of IL-6, which correlated significantly with the degree of disability, promoting it as a significant therapeutic target.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt

Samaan

Taha

2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…Hypertriglyceridemia had a significant independent effect on cartilage metabolism and could make cartilage homeostasis change to degeneration. 40 BMI-related central obesity is another important component of the metabolic syndrome, and up to two-thirds of elderly obese people are affected by KOA. 41 Obese people may have considerable overload and injury to their weightbearing joints due to weight increase brought on by elevated BMI.…”

Section: Metabolic Syndrome and Bone Metabolismmentioning

confidence: 99%

Research Progress on the Pathogenesis of Knee Osteoarthritis

Liu

Tao

et al. 2023

Orthopaedic Surgery

View full text Add to dashboard Cite

Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro‐ and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment.

show abstract

“…Higher total and non-HDL cholesterol was associated with increased cartilage degeneration in a cross-sectional MRI study investigating MetS-OA [ 32 ]. Further, in patients with early-stage disease, namely KL I and II knee OA with and without MetS, significant increases in serum COMP, a biomarker of cartilage degeneration, in MetS-OA was noted when compared to non-MetS OA, and positively correlated with hypertriglyceridemia [ 33 ]. Serum PIIANP, a marker of cartilage regeneration [ 34 ], was not statistically different between the MetS and non-MetS OA groups, the authors maintaining that the predominant effect of MetS is catabolism, without significantly effecting repair processes [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, in patients with early-stage disease, namely KL I and II knee OA with and without MetS, significant increases in serum COMP, a biomarker of cartilage degeneration, in MetS-OA was noted when compared to non-MetS OA, and positively correlated with hypertriglyceridemia [ 33 ]. Serum PIIANP, a marker of cartilage regeneration [ 34 ], was not statistically different between the MetS and non-MetS OA groups, the authors maintaining that the predominant effect of MetS is catabolism, without significantly effecting repair processes [ 33 ]. These findings add further evidence to the notion that MetS tips cartilage homeostasis towards catabolism in early knee OA in a dose-response manner.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Osteoarthritis—A Narrative Review on Causal Links with Metabolic Syndrome

Lynskey

Macaluso

Gill

et al. 2023

Life

View full text Add to dashboard Cite

Development of OA (OA) is multifactorial and is strongly associated with risk factors such as aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA, collectively coined MetS-OA, is an increasingly recognized entity in which metabolic disorders and low-grade inflammation play a key mechanistic role in the disruption of joint homeostasis and cartilage degradation. Although there have been enormous efforts to discover biomarkers of MetS and OA, studies investigating a pathophysiological link between MetS and OA are relatively limited, and no serum blood marker has proved diagnostic so far. OA biomarkers that are necessary to discriminate and diagnose early disease remain to be elicited, explained in part by limited prospective studies, and therefore limited tools available to utilize in any prognostic capacity. Biomarker validation projects have been established by the Biomarker Consortium to determine biochemical markers demonstrating predictive validity for knee OA. Given that the metabolic constituents of MetS are treatable to varying extents, it stands to reason that treating these, and monitoring such treatment, may help to mitigate deleterious links with OA development. This narrative review will describe the current state of biomarker identification and utility in OA associated with MetS. We discuss the pathophysiological mechanisms of disease according to constituent pathologies of MetS and how identification of biomarkers may guide future investigation of novel targets.

show abstract

Metabolic Syndrome and Its Effects on Cartilage Degeneration vs Regeneration: A Pilot Study Using Osteoarthritis Biomarkers

Cited by 7 publications

References 22 publications

The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt

The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt

Research Progress on the Pathogenesis of Knee Osteoarthritis

Biomarkers of Osteoarthritis—A Narrative Review on Causal Links with Metabolic Syndrome

Contact Info

Product

Resources

About