Metabolic syndrome and its components among women with polycystic ovary syndrome: a systematic review and meta-analysis

Abstract

Introduction: The objectives of this study were to provide an estimate of the prevalence of metabolic syndrome (MetS ) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different definitions of MetS) in women with PCOS, compared to healthy controls. Methods: All of the relevant databases were used to search for appropriate articles that were published during the period 2003-2016. We included observational studies (cross-sectional, comparative cross-sectional) among women who met the inclusion criteria. The random-effect models were used to pool the prevalence of MetS and its components among PCOS women. This model was also applied to the pooled OR assessing the association between MetS and PCOS. Results: The pooled prevalence of MetS among PCOS women was found to be 26.30% (95% CI: 23.68–28.93), but varied from 7.10% (95% CI: 1.64-12.56) to 37.50% (95% CI: 28.84-46.16), depending upon the diagnostic criteria used. Low high-density lipoprotein cholesterol (HDL) - 61.87% (95% CI: 53.31–70.43) and high waist circumference (WC)- 52.23% (95% CI: 43.84–60.61) were the most common components of MetS in PCOS women. Compared to healthy controls, the overall pooled (OR) of MetS in PCOS patients was 2.09 (95% CI: 1.67-2.60), but this ranged from 0.31 (95% CI: 0.13-0.74) to 4.69 (95% CI: 2.09-10.52), depending upon the diagnostic criteria used. Conclusion: Women with PCOS had a much higher prevalence of MetS than was found among the healthy controls. Furthermore, as low HDL and high WC were the most common components of MetS in PCOS women, these two components specifically need to be addressed in prevention strategies.

<p>Correlation Between Recovery of Menstrual Cycle and Improvement of Glucose and Lipid Metabolism in Patients with Sleeve Gastrectomy in a Small Chinese Cohort Sample</p>

“…9 Lipid-lowering drugs have been proved to improve glucose and lipid metabolism in obese patients with PCOS, and can assist in improving ovulation induction effect. 10 It is difficult to achieve clinical effect with a single treatment for the three major pathological parts. For PCOS patients, the first recommendation is to adjust lifestyle, namely introduce proper exercise and reasonable diet structure, which is beneficial to long-term management of menstruation.…”

“… 9 Lipid-lowering drugs have been proved to improve glucose and lipid metabolism in obese patients with PCOS, and can assist in improving ovulation induction effect. 10 It is difficult to achieve clinical effect with a single treatment for the three major pathological parts.…”

Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome

“…The prevalence of metabolic syndrome has been shown to be higher in women with PCOS compared to control populations, with an overall pooled odds ratio of 2.09 in a recent meta-analysis (34), with a low high density lipoprotein (HDL), and high waist circumference being the most common components found. As noted above, given that waist circumference is a surrogate marker for cardiovascular disease, more so than BMI (32, 33), and the association of a low HDL with cardiovascular disease, the evidence suggests that these issues need to be addressed in prevention strategies (34).…”

How to Screen and Prevent Metabolic Syndrome in Patients of PCOS Early: Implications From Metabolomics

“…Moreover, a meta-analysis of 107 studies by Jamal Hallajzadeh et al. showed a significant relationship between PCOS and MS ( 4 ). Therefore, PCOS should no longer be considered as a simple gynecological disease.…”