Metabolic profiling, antioxidant, and antibacterial activity of some Iranian Verbascum L. species

Selseleh, Mohammad; Ebrahimi, Samad Nejad; Aliahmadi, Atousa; Sonboli, Ali; Mirjalili, Mohammad Hossein

doi:10.1016/j.indcrop.2020.112609

Cited by 36 publications

(45 citation statements)

References 69 publications

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“…Here, of the nine identified phenolic compounds, only rosmarinic acid had a striking concentration in the MLACs ( Figure 5, b ). Due to the value of phenolic compounds in the nutrition, beverage, cosmetic, and pharmacology as antibacterial and antioxidant agents, [70] phenolic acid of MLACs can be considered in domestication and breeding projects for more exploitation.…”

Section: Resultsmentioning

confidence: 99%

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Araghi

Nemati

Azizi

et al. 2021

Chemistry & Biodiversity

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Mentha longifolia L. is well‐known to be one of the most pervasive wild‐growing species of the Lamiaceae family, which has extensive beneficial properties in the fields of pharmacology and biological products. In the present study, the correlation between Inter‐simple sequence repeat (ISSR) markers and morpho‐chemical parameters of twenty different M. longifolia accessions (MLACs) were assessed. The geographic information system (GIS) has been employed to interpret the original habitat of the accessions in Iran. ISSR analysis indicated a remarkable difference in the studied accessions, segregated them into three main groups, constructed by an unweighted pair‐group method with arithmetic (UPGMA) and principal coordinate analysis (PCoA). A total of 89 bands were generated by 12 ISSR primers, among which 82 (91.97 %) of them were polymorphic. The cluster analysis based on agro‐morphological data scattered MLACs into two main groups. The essential oils (EOs) were analyzed through GC/FID/MS, and four chemotypes were characterized according to the major constituents. Pulegone ranged from 0.17 to 69.50 % was the main oil constituent with the highest content. Also, HPLC‐PDA was employed to identify and to quantify the phenolic compounds in the MeOH extracts of MLACs. Heatmap cluster based on phenolic compounds produced three main categories of accessions. The components identified in the extracts were rosmarinic acid, rutin, vanillic acid, ferulic acid, chlorogenic acid, caffeic acid, 3,4‐dihydroxybenzoic acid, 2,5‐dihydroxybenzoic acid, and p‐coumaric acid, which among them rosmarinic acid (RA) varied from 39.16 to 261.55 mg/100 g (DW) as a predominant constituent. Subsequently, multiple regression analyses between ISSR fragments and morpho‐chemical data illustrated considerable relationships in the plant materials. The high variation and correlation observed in metabolic and phenotypic traits of MLACs establish an adequate source to conduct reserves conservation programs.

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Section: Resultsmentioning

confidence: 99%

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Araghi

Nemati

Azizi

et al. 2021

Chemistry & Biodiversity

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“…A review of studies shows that the amount of chemical compounds such as phenol and flavonoids in the plant depends more on the type of plant organ, the type of species, and the place of plant growth and environmental factors than on the time of harvest [ 43 – 45 ]. The results of the studies showed that the extract of V. sinuatum contains the highest amount of phenolic compounds and antioxidant activity [ 44 , 46 , 47 ]. In the study of Selseleh et al, The contents of phenol and flavonoids of V. sinuatum were higher than that of V. Thapsus [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results of the studies showed that the extract of V. sinuatum contains the highest amount of phenolic compounds and antioxidant activity [ 44 , 46 , 47 ]. In the study of Selseleh et al, The contents of phenol and flavonoids of V. sinuatum were higher than that of V. Thapsus [ 47 ]. Moreover in the study of Karimian and Ghasemlou, the phenolic compounds of V. sinuatum (118.2 ± 2.46 mg / g dry weight) were higher than the phenols of V. Thapsus in the present study.…”

Section: Discussionmentioning

confidence: 99%

The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial

Taleb

Saeedi

2021

BMC Complement Med Ther

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Background The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it has been used since ancient times to treat wounds. Therefore, this study aimed to evaluate the effect of Verbascum Thapsus on episiotomy wound healing. Methods The study was designed as a randomized, double-blind, controlled clinical trial. Ninety-three primiparous women who were referred to Fatemeh Zahra Hospital in Saveh in 2015 were randomly divided into two groups of intervention (Verbascum Thapsus) and control (placebo). Both groups covered the episiotomy wound twice a day for 10 days with 2 cm of prescribed creams. Wound healing was assessed using the REEDA scale before the intervention and on days 1,3 and 10 after the intervention. Results Before the intervention, there was no statistically significant difference in terms of demographic characteristics, obstetrics, and REEDA scores between the two groups (p < 0.05). The mean scores of REEDA on days 1 and 3 in the intervention group were better than the control group but were not statistically significant. However, on the tenth day after the intervention, the mean scores of REEDA were significantly better in the Verbascum group than the placebo (p = 0.01). Conclusions According to the results of this study, it seems that Verbascum Thapsus is effective in repairing episiotomy wounds. The researchers hope that the results of this study can provide clinical evidence for the use of this herbal medicine in the wound healing process. Trial registration This study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT201404073106N15” on 02/12/2015.

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“…Today, literatures are filled with accumulating evidence emphasizing on the need to continuously screen medicinal plants in order to reveal key details on their medicinal values. Indeed, with years, the extensive growth of pharmaceutical, nutraceutical, cosmeceutical, or food industries have significantly increased the demand for medicinal plants and their respective bioactive compounds [2] …”

Section: Introductionmentioning

confidence: 99%

Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives

Mahomoodally

Zengin

Sinan

et al. 2021

Chemistry & Biodiversity

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The aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.‐Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer‐assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α‐amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.

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Metabolic profiling, antioxidant, and antibacterial activity of some Iranian Verbascum L. species

Cited by 36 publications

References 69 publications

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial

Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives

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