The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial

Abstract

Background The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it has been used since ancient times to treat wounds. Therefore, this study aimed to evaluate the effect of Verbascum Thapsus on episiotomy wound healing. Methods The study was designed as a randomized, double-blind, controlled clinical trial. Ninety-three primiparous women who were referred to Fatemeh Zahra Hospital in Saveh in 2015 were randomly divided into two groups of intervention (Verbascum Thapsus) and control (placebo). Both groups covered the episiotomy wound twice a day for 10 days with 2 cm of prescribed creams. Wound healing was assessed using the REEDA scale before the intervention and on days 1,3 and 10 after the intervention. Results Before the intervention, there was no statistically significant difference in terms of demographic characteristics, obstetrics, and REEDA scores between the two groups (p < 0.05). The mean scores of REEDA on days 1 and 3 in the intervention group were better than the control group but were not statistically significant. However, on the tenth day after the intervention, the mean scores of REEDA were significantly better in the Verbascum group than the placebo (p = 0.01). Conclusions According to the results of this study, it seems that Verbascum Thapsus is effective in repairing episiotomy wounds. The researchers hope that the results of this study can provide clinical evidence for the use of this herbal medicine in the wound healing process. Trial registration This study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT201404073106N15” on 02/12/2015.

Gold Nanoparticles Synthesized with Common Mullein (Verbascum thapsus) and Castor Bean (Ricinus communis) Ethanolic Extracts Displayed Antiproliferative Effects and Induced Caspase 3 Activity in Human HT29 and SW480 Cancer Cells

“…Hence, the castor extract presented the highest range of total phenolic compounds with 101.32 ± 0.81 mg GAE/g DW. The obtained ME-TPC was consistent with previous reports of V. thapsus aerial and flower extracts (44.84–60.13 mg GAE/g DW or mL extract) [ 35 , 36 ], although Taleb et al [ 36 ] did not specify the amount of powdered extract used, and the flowers were subjected to several ethanolic extractions (96% v / v ) by maceration.…”

Effect of Rosemary Cream on Episiotomy Wound Healing in Primiparous Women: A Randomized Clinical Trial

“…Episiotomy is a surgery conducted to enlarge the vaginal orifice by making an incision in the perineum during the late second stage of labor [1] to facilitate the expulsion of the fetus [2] and reduce grades 3 and 4 perineal Hadizadeh-Talasaz et al BMC Complementary Medicine and Therapies (2022) 22:226 tears occurring during the second stage of labor [3]. Although episiotomy is the most common surgical procedure in obstetrics [4], the use of this surgical method has decreased nowadays due to the lack of evidence on its protective effects against anal sphincter injuries caused by vaginal delivery [1].…”

“…Regarding the side effects of synthetic drugs, the use of medicinal plants is a better option in wound healing due to minimal side effects and cost-effectiveness, compared to synthetic compounds [28]. The medicinal application of plants requires clinical evidence [3]; however, no study has yet examined the effect of rosemary on episiotomy wound healing. Therefore, this study aimed to evaluate the effect of rosemary cream on episiotomy wound healing in primiparous women.…”