Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats

Abstract

The present study aimed to investigate the metabolic perturbations and health impacts of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and Nε-(carboxymethyl)lysine (CML), via serum biochemical and...

Health effects of exposure to β-carboline heterocyclic amines: insight into metabolic perturbations and biochemical analysis

“…1E). Although our previous study showed that intake of harmane alleviated abnormal blood glucose metabolism caused by exposure to acrylamide, 19,20 the results of the present study showed that the intake of exogenous harmane did not play a positive role in the insulin resistance and abnormal blood glucose metabolism in GK rats.…”

“…The doses of harmane in this study were selected based on the concentration of harmane in various foodstuffs, 6,12,23 with reference to the experimental doses employed in our previous studies and by other researchers. 19 Moreover, owing to the exposure time and interspecies and intraspecies differences, as shown in previous studies, 24 the safety and uncertainty factors of this chemical were chosen to compensate for human exposure and convert it to an appropriate rat dose that is comparable to human exposures from a daily diet high in β-carboline HA levels.…”

“…18 However, our previous studies demonstrated that although harmane could alleviate the disturbance of blood glucose metabolism and the oxidative inflammatory stress levels caused by other harmful substances from foodstuffs such as acrylamide and CML, 19,20 it also led to pathological injury to the liver and kidneys, resulting in the abnormal metabolism of fumaric acid and the TCA cycle. 19,20 Therefore, the question is whether β-carboline HAs in foodstuffs we eat have effects on human health. Considering the current trend of rapidly increasing diabetes and complications worldwide, and the influence of dietary components on the development of diabetes and complications, and based on the finding of our previous research, 21,22 the main purpose of this study is to investigate the health effects of a typical β-carboline HA (harmane) on diabetic Goto-Kakizaki (GK) rats through serum biochemistry tests, histopathological examinations, and serum and urine metabolomic analyses.…”

“…A recent study indicated that long-term consumption of a diet rich in β-carboline may be effective for preventing certain diseases. 18 However, our previous studies demonstrated that although harmane could alleviate the disturbance of blood glucose metabolism and the oxidative inflammatory stress levels caused by other harmful substances from foodstuffs such as acrylamide and CML, 19,20 it also led to pathological injury to the liver and kidneys, resulting in the abnormal metabolism of fumaric acid and the TCA cycle. 19,20…”

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

“…At present, most studies used heat‐treated foods for feeding mice to study the effects of dietary AGEs intake on organismal health (Luo, Li, et al, 2022; Roncero‐Ramos et al, 2013). However, extensive heat processing foods contain various antinutritional and toxic compounds derived from the Maillard reaction (e.g., acrylamide [Quan et al, 2022], heterocyclic aromatic amines [Dong et al, 2020], and 5‐hydroxymethylfurfural [Han et al, 2019; Pérez‐Burillo et al, 2019]). Notably, Pouillart et al (2010) confirmed that the content of acrylamide and 5‐hydroxymethylfurfural were significantly higher in heat‐treated foods which had high AGEs content.…”