Metabolic networks of the human gut microbiota

Selber-Hnatiw, Susannah; Sultana, Tarin; Tse, William Ka Fai; Abdollahi, Niki; Abdullah, Sheyar; Rahbani, Jalal Al; Alazar, Diala; Alrumhein, Nekoula Jean; Aprikian, Saro; Arshad, Rimsha; Azuelos, Jean-Daniel; Bernadotte, Daphney; Beswick, Natalie; Chazbey, Hana; Church, Kelsey; Ciubotaru, Emaly; D'Amato, Lora; Corpo, Tavia Del; Deng, Jasmine; Giulio, Briana Laura Di; Diveeva, Diana; Elahie, Elias; Frank, James Gordon Marcel; Furze, Emma; Garner, Rebecca E.; Gibbs, Vanessa; Goldberg-Hall, Rachel; Goldman, Chaim Jacob; Goltsios, Fani-Fay; Gorjipour, Kevin; Grant, Taylor; Greco, Brittany; Guliyev, Nadir; Habrich, Andrew; Hyland, Hillary; Ibrahim, Nabila M.; Iozzo, Tania; Jawaheer-Fenaoui, Anastasia; Jaworski, Julia Jane; Jhajj, Maneet Kaur; Jones, Jermaine D.; Joyette, Rodney; Kaudeer, Samad; Kelley, Shawn; Kiani, Shayesteh; Koayes, Marylin; Kpata, Abby Johanna Amy-Aminta Léna; Maingot, Shannon; Martin, Sara De; Mathers, Kelly; McCullogh, Sean; McNamara, Kelly; Mendonça, James D.; Mohammad, Karamat; Momtaz, Sharara Arezo; Navaratnarajah, Thiban; Nguyen-Duong, Kathy; Omran, Mustafa; Ortiz, Angela; Patel, Anjali; Paul-Cole, Kahlila; Plaisir, Paul-Arthur; Marroquin, Jessica Alexandra Porras; Prevost, Ashlee; Quach, Angela; Rafal, Aries John; Ramsarun, Rewaparsad; Rhnima, Sami; Rili, Lydia; Safir, Naomi; Samson, Eugenie; Sandiford, Rebecca Rose; Secondi, Stefano; Shahid, Stephanie; Shahroozi, Mojdeh; Sidibé, Fily; Smith, Megan; Flores, Alina Maria Sreng; Ybarra, Anabel Suarez; Sénéchal, Rebecca; Taifour, Tarek; Tang, Lynn; Trapid, Adam; Potvin, Maxim Tremblay; Wainberg, Justin; Wang, Dani Ni; Weissenberg, Mischa; White, Allison; Wilkinson, Gabrielle; Williams, Brittany; Wilson, Joshua Roth; Zoppi, Johanna; Zouboulakis, Katerina; Gamberi, Chiara

doi:10.1099/mic.0.000853

Cited by 24 publications

(30 citation statements)

References 348 publications

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“…The human gut contains a wide variety of microbial communities that carry out a wide range of biochemical functions that can influence the human body through metabolite production, physiological regulation, and interacting with the host’s cellular response and immunity[ 52 ]. It has also been found that the host’s own genetics can influence the composition of their gut microbiome, making each host a unique ecosystem[ 53 ].…”

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

“…SCFAs produced by GM can serve as signaling molecules that can influence the host’s lipid and glucose levels, liver, skeletal muscle, and even immunity[ 52 ]. When there is a disruption of the gut microbiome, the altered mixture of SCFA may influence obesity, insulin sensitivity, weight gain and other comorbidities[ 58 , 59 ].…”

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

“…The GM has been found to influence the host’s metabolism and show great adaptability to the changing environment within the intestines based on diet, genetics, and various physiological cues from the host[ 52 ]. The human gut microbiome can modulate absorption as well as nutrient availability within the host.…”

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

“…The human gut microbiome can modulate absorption as well as nutrient availability within the host. This can be achieved through gene expression changes, alteration of hormones and immunity[ 52 ].…”

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

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Holistic perspective of the role of gut microbes in diabetes mellitus and its management

Alagiakrishnan¹,

Halverson²

2021

WJD

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The gut microbiota (GM) plays a role in the development and progression of type 1 and type 2 diabetes mellitus (DM) and its complications. Gut dysbiosis contributes to the pathogenesis of DM. The GM has been shown to influence the efficacy of different antidiabetic medications. Intake of gut biotics, like prebiotics, probiotics and synbiotics, can improve the glucose control as well as the metabolic profile associated with DM. There is some preliminary evidence that it might even help with the cardiovascular, ophthalmic, nervous, and renal complications of DM and even contribute to the prevention of DM. More large-scale research studies are needed before wide spread use of gut biotics in clinical practice as an adjuvant therapy to the current management of DM.

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Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

Section: Gut Microbes and Metabolic Networkmentioning

confidence: 99%

See 2 more Smart Citations

Holistic perspective of the role of gut microbes in diabetes mellitus and its management

Alagiakrishnan¹,

Halverson²

2021

WJD

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“…For this month’s musings we start with a couple of articles about bacterial metabolism. The first is an interesting and novel review of metabolic networks found in the human gut microbiome [ 1 ]. It is novel in that it was written as a collaborative effort by a consortium of undergraduate students studying microbiology at Concordia University in Montréal, Canada, led by Chiara Gamberi ( @ChiaraGamberi ), following a model that she used in 2019 [ 2 ].…”

mentioning

confidence: 99%