Gut-host Crosstalk: Methodological and Computational Challenges

Ivanov, Ivan

doi:10.1007/s10620-020-06105-9

Cited by 2 publications

(1 citation statement)

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“…Continuing development of computational analysis tools for the analysis of metabolomic data, similar to the tools available for microbiota composition analysis, is important to overcome analytical challenges non-specialist labs currently face. 141 Another important challenge is the translation from mouse models to humans. In vitro screening methods for human-derived commensal microbes are key for translating mouse data to the human situation.…”

Section: Resultsmentioning

confidence: 99%

Microbial modulation of intestinal T helper cell responses and implications for disease and therapy

Geuking

Burkhard

2020

Mucosal Immunology

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Induction of intestinal T helper cell subsets by commensal members of the intestinal microbiota is an important component of the many immune adaptations required to establish host-microbial homeostasis. Importantly, altered intestinal T helper cell profiles can have pathological consequences that are not limited to intestinal sites. Therefore, microbial-mediated modulation of the intestinal T helper cell profile could have strong therapeutic potentials. However, in order to develop microbial therapies that specifically induce the desired alterations in the intestinal T helper cell compartment one has to first gain a detailed understanding of how microbial composition and the metabolites derived or induced by the microbiota impact on intestinal T helper cell responses. Here we summarize the milestone findings in the field of microbiota-intestinal T helper cell crosstalk with a focus on the role of specific commensal bacteria and their metabolites. We discuss mechanistic mouse studies and are linking these to human studies where possible. Moreover, we highlight recent advances in the field of microbial CD4 T cell epitope mimicry in autoimmune diseases and the role of microbially-induced CD4 T cells in cancer immune checkpoint blockade therapy.

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Section: Resultsmentioning

confidence: 99%