Metabolic Evaluation of Urolithiasis and Obesity in a Midwestern Pediatric Population

Roddy, John T.; Ghousheh, Anas I.; Christensen, Melissa; Durkee, Charles T.

doi:10.1016/j.juro.2013.09.064

Cited by 14 publications

(4 citation statements)

References 17 publications

(27 reference statements)

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“…17 Additional studies on pediatric urolithiasis reached the same conclusion. 3,21 In the current study, although American children were heavier (Table 2), the percentage of those being overweight did not exceed the percentage in the general pediatric school-age population of 17.0% per recent data from the Centers for Disease Control and Prevention. 22 Although national data regarding obesity in the Brazilian pediatric population were not fully available, a recent school-based cross-sectional study by Silva et al 23 involving 41 654 students showed that the growth in body weight, height, and BMI in urban areas is increasingly similar to those reported in developed countries.…”

Section: Discussionmentioning

confidence: 43%

American and Brazilian Children With Primary Urolithiasis

Penido

Tavares

Guimarães

et al. 2014

Global Pediatric Health

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Objectives. Considering the differences in location, socioeconomic background, and cultural background, the aim of this study was to try to identify possible factors associated with the increased incidence of urolithiasis by comparing American and Brazilian children with stones. Methods. Data of 222 American and 190 Brazilian children with urolithiasis were reviewed including age, gender, body mass index, imaging technique used (ultrasound and computed tomography), and 24-hour urine volume and chemistries. Results. There were no differences between age and gender at diagnosis. Brazilian children were leaner but in no population did obesity rate exceed that of the general population. Ultrasound was most commonly used to diagnose stones, even more so in Brazilians. Decreased urine flow was more common among Americans (P = .004), hypercalciuria among Brazilians (P = .001), and elevated Ca/citrate ratio among Americans (P = .009). There were no differences between the groups in the frequency of hypocitraturia, hyperuricosuria, absorptive hyperoxaluria, and cystinuria. Conclusions. Despite some differences between the populations, the leading causes of urolithiasis among both were “oliguria,” hypercalciuria, and high Ca/citrate ratio. In neither country was obesity the reason for the increase in incidence of urolithiasis, nor was the use of computed tomography. The similarities between the 2 populations call for combining efforts in addressing the leading causes of pediatric urolithiasis.

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Section: Discussionmentioning

confidence: 43%

American and Brazilian Children With Primary Urolithiasis

Penido

Tavares

Guimarães

et al. 2014

Global Pediatric Health

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“…Eisner et al found that as BMI increased, urine oxalate excretion decreased and super-saturation of calcium phosphate increased [18]. Other recent studies support that there may be no substantial metabolic differences between healthy non-obese and obese stone formers [19][20][21]. In contrast, another retrospective study found that overweight and obese stone forming children were more likely to have decreased levels of urine citrate, phosphate, and magnesium and increased hypercalcuria when compared with patients with normal BMI [22].…”

Section: Discussionmentioning

confidence: 98%

24 Hour urine metabolic differences between solitary and multiple stone formers: Results of the Collaboration on Urolithiasis in Pediatrics (CUP) working group

Saitz

Mongoue-Tchokote

Sharadin

et al. 2017

Journal of Pediatric Urology

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“…Another study found no significant relationship between BMI and urolithiasis, but did find a significant decrease in the odds of urolithiasis in black race and Medicaid payer status [13]. While the aforementioned studies collectively do not identify a definitive relationship between obesity and kidney stones in children, longitudinal studies may be warranted [2,[14][15][16][17][18].…”

Section: Epidemiologymentioning

confidence: 99%

Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review

Paiste

Moradi

Assimos

et al. 2021

Uro

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Objectives: To examine the most recent literature and published science in determining any and all possible associations between pediatric obesity and pediatric urolithiasis. Methods: Retrospective literature review of pediatric stone formers with diagnosed stone disease and all associated risk factors. Peer-reviewed, published manuscripts from the past several decades were analyzed for risk factors associated with pediatric obesity such as diet, hypertension, and renal diseases. Comparing the pediatric obesity literature with the pediatric stone forming literature, any associations and correlations were derived and analyzed. Results: Despite the existing evidence that obesity is linked to stones in adults, the evidence remains unclear whether obesity plays a role in children. Nutritional discrepancies, in the setting of the obesity epidemic, have been shown to alter the risk profile of pediatric patients. Consistent with the published literature, and lack of consistent correlation with obesity and stone disease, is the knowledge that age, gender, geography, and climate may all play a role in the onset of pediatric obesity and may also be on the causal pathway toward pediatric urolithiasis. Conclusion: The manuscript demonstrates that there are a number of risk factors, congenital or acquired, that are associated with pediatric obesity. The mechanisms responsible for these associations may be on the causal pathway toward childhood urolithiasis. These mechanisms that underlie these associations need to be further investigated.

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Metabolic Evaluation of Urolithiasis and Obesity in a Midwestern Pediatric Population

Cited by 14 publications

References 17 publications

American and Brazilian Children With Primary Urolithiasis

American and Brazilian Children With Primary Urolithiasis

24 Hour urine metabolic differences between solitary and multiple stone formers: Results of the Collaboration on Urolithiasis in Pediatrics (CUP) working group

Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review

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