Metabolic and oxidative status of Saanen goats of different parity during the peripartum period

Abstract

The aim of this study was to research changes in metabolic and antioxidative status of Saanen goats of different parity occurring during the peripartum period. Blood samples were taken on 10-7 and 3-1 d prepartally and 1-3, 14 and 28 d postpartally from goats allocated in three groups according to their parity: primiparous (PRIM), goats that kidded the 2nd or 3rd time (MID), and goats that kidded 4 or more times (MULTI)). Metabolic profile parameters (non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), glucose, triglycerides, albumin and urea) and indicators of oxidative stress ((superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)) were determined. Intense metabolic changes associated with late pregnancy and onset of lactation were pronounced the most in MULTI goats that also had the biggest litter per goat. Significant differences were found in metabolic parameters NEFA, BHB, glucose, triglycerides within groups during peripartum period, as well as between them (the effect of parity). MDA concentrations were indicative of increased lipid peroxidation around parturition, especially pronounced in MULTI group 1-3 d prepartally, when the highest GSH-Px/SOD ratio was also found. Postpartally, antioxidant enzymes ratio in MID and MULTI group decreased while MDA concentrations remained high, suggesting antioxidant system inefficiency. Significant time × group interaction was observed for most of the parameters. The obtained results show that the goats of higher parity display higher levels of metabolism intensity and consequently, varying levels of oxidative stress during the peripartum period. Further studies should determine applicability of NEFA and BHB in periparturient metabolic profiling in dairy goats as well as establish normal ranges and cut-off levels for these biomarkers.

Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

“…A similar trend that serum glucose concentration was higher in early lactation compared to late pregnancy in WAD goats was reported by Radin et al (2015) for Saanen goats. Protein is an essential component of cells, and during gestation, the protein is required for fetal growth and maintenance of the dam; this accounts for the increase in serum total protein as gestational age.…”

“…Similarly, udder uses a large amount of protein for milk production during lactation (Quiroz-Rocha et al 2009) which could explain the increased albumin levels of postpartum WAD does as obtained in this study and Radin et al (2015) in Saanen goats. Serum cholesterol and high-density lipoprotein increased progressively with the stage of gestation, with dry does having statistically least values.…”

Blood metabolites of extensively reared Croatian multi-coloured goats during early lactation and early gravidity

“…To our knowledge, there are no reference values for NEFA in goats; KANEKO et al (2008) mention a very wide range for cows (0.378 -3.78 mmol/L), but none for sheep and goats. NEFA values in this research were significantly higher (P<0.0001) in early lactation L. Radin et al: Blood metabolites of Croatian multi-coloured goat (March) than at the beginning of gravidity (October), which is consistent with results for sheep, goats and cows published by various authors (EŞKI et al, 2015;RADIN et al, 2015). This rise corresponds to physiological adaptation to gravidity and the beginning of lactation.…”

Oxidative Status of Goats with Different CSN1S1 Genotypes Fed ad Libitum with Fresh and Dry Forages

“…Changes in total oxidative and antioxidant status were observed in local goats from early lactation to late lactation period and it was supposed to be associated to a different lipomobilization occurring in adipose tissue along the lactation period [10]. An influence of parity on the occurrence of peripartum redox imbalance was also observed when the metabolic and antioxidative status of Saanen goats of different parity were compared [11].…”