Metabolic and Immune Effects of Arginine in Postinjury Hyperalimentation

Barbul, Adrian; Sisto, Donato; Wasserkrug, Hannah L.; Yoshimura, N; Efron, Gershon

doi:10.1097/00005373-198111000-00011

Cited by 47 publications

(10 citation statements)

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“…With regard to the immune system, arginine has 2 important roles: production of nitric oxide (NO) and lymphocyte function. Three isoforms of NO synthase (endothelial, inducible, and neuronal) transform arginine into systemic NO . NO has been shown to be an intracellular signaling molecule, influencing a multitude of mammalian organ systems.…”

Section: Possible Nutrition Interventionsmentioning

confidence: 99%

“…Three isoforms of NO synthase (endothelial, inducible, and neuronal) transform arginine into systemic NO. 8,[68][69][70][71][72][73][74][75][76] NO has been shown to be an intracellular signaling molecule, influencing a multitude of mammalian organ systems. NO is also responsible for improved bactericidal action in macrophages.…”

Section: Protein and Anabolic Supplementsmentioning

confidence: 99%

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Chronic Critical Illness: Application of What We Know

et al. 2018

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Over the last decade, chronic critical illness (CCI) has emerged as an epidemic in intensive care unit (ICU) survivors worldwide. Advances in ICU technology and implementation of evidence-based care bundles have significantly decreased early deaths and have allowed patients to survive previously lethal multiple organ failure (MOF). Many MOF survivors, however, experience a persistent dysregulated immune response that is causing an increasingly predominant clinical phenotype called the persistent inflammation, immunosuppression, and catabolism syndrome (PICS). The elderly are especially vulnerable; thus, as the population ages the prevalence of this CCI/PICS clinical trajectory will undoubtedly grow. Unfortunately, there are no proven therapies to prevent PICS, and multimodality interventions will be required. The purpose of this review is to: (1) discuss CCI as it relates to PICS, (2) identify the burden on healthcare and poor outcomes of these patients, and (3) describe possible nutrition interventions for the CCI/PICS phenotype.

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Section: Possible Nutrition Interventionsmentioning

confidence: 99%

Section: Protein and Anabolic Supplementsmentioning

confidence: 99%

Chronic Critical Illness: Application of What We Know

et al. 2018

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“…[8][9][10][11] Not only is collagen accumulation increased by arginine supplementation, but peripheral blood lymphocytes show increased mitogenesis and activity as well. Although arginine improves epithelial reconstitution after intestinal injury, 12 it has no effect on the reepithelialization of skin graft donor sites in patients or volunteers, whether given orally or parenterally.…”

Section: Amino Acidsmentioning

confidence: 99%

Immunonutrition: Role in Wound Healing and Tissue Regeneration

Chow

Barbul

2014

Advances in Wound Care

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“…These include the release of somatotropin and prolactin from the hypophysis and promotion of release of insulin. 8,9 In addition, the production of insulin-like growth factor (IGF) and the release of glucagon, somatostatin, pancreatic polypeptides, and catecholamines are enhanced by ARG. 10 Moreover, ARG is the precursor of polyamines (putrescine, spermine, and spermidine).…”

Section: Arginine Metabolismmentioning

confidence: 99%