Immunonutrition: Role in Wound Healing and Tissue Regeneration

Chow, Oliver; Barbul, Adrian

doi:10.1089/wound.2012.0415

Cited by 101 publications

(80 citation statements)

References 41 publications

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“…Laboratory studies at the time of presentation, including hematology, serum chemistries, and nutritional parameters, will also provide useful information to supplement initial impressions. 32 An assessment of the patients' living situation and their likely reliability in following prescribed treatments is important in the actual determination of which therapies should be employed to manage the wound(s).…”

Section: Patient and Wound Assessmentmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,708

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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Section: Patient and Wound Assessmentmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,708

1,429

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“…A favourable immunomodulatory action is also attributed to such ingredients as the above-mentioned: copper, zinc, iron, vitamins B2, B6, C and E. Immunomodulatory ingredients can be added both to the mixtures intended for nutrition via the gastrointestinal tract (oral or enteral) and for parenteral nutrition. [21][22][23][24][25] It has been proved that the use of mixtures of nutrients with immunomodulatory action diminishes the risk of infection and shortens the total duration of hospital stay. Particularly favourable effects were achieved among the patients with concomitant malnutrition, compared to the well-nourished patients.…”

Section: Discussionmentioning

confidence: 99%

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

Kuczyńska

2017

NPWTJ

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Abstract-Introduction: Wound healing process depends on many factors. As it has been proved many times before, nutrition is one of the key factors in wound healing therapy. When there is an insufficient supply of nutrients and malnutrition, wound healing processes slow down and the inflammatory phase is prolonged, which requires high energy expenditure and as a consequence, may lead to the loss of lean body mass and the development of sarcopenia and cachexia. This promotes the formation of non-healing chronic wounds.In this paper we would like to emphasize the role of nutrition, as an integral part of wound healing processes, which should encompass the current metabolic needs associated with patient's clinical condition.Case report: This case describes a young male patient with gastrointestinal tract insufficiency and an extensive postoperative wound treated by the open abdomen method. In the course of increased catabolism, water and electrolyte loss and disturbances as well as nutritional insufficiencies, body mass loss and progressive cachexia occurred in this patient and, as a consequence, the wound healing processes was significantly diminished.Conclusions: Inducing and maintaining the anabolic processes in the organism and control of the enhanced catabolism in response to metabolic stress or injury are essential actions in optimizing the treatment and healing process. These are possible to achieve by the early introduction of balanced and individualized nutritional treatment regimens, provision of the energy and appropriate nutrients, which enables the restoration of lean body mass and stimulation of the healing processes.

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“…Infection delays wound healing and is directly influenced by the nutritional status of the patient and the presence of a functioning immune function [27,28]. In gynecologic surgical patients, infectious complications rise in relation to the degree of patients' nutritional deficiencies [29•].…”

Section: Wound Infectionmentioning

confidence: 99%

“…In gynecologic surgical patients, infectious complications rise in relation to the degree of patients' nutritional deficiencies [29•]. Immunomodulatory diets, a new topic of research, decrease infectious complications in wounds and in patients with cancer [27]. A metaanalysis of 18 randomized clinical trials implementing IMPACT formula supplementation perioperatively showed significant reductions in hospital LOS, infectious complications, and, in the case of GI surgeries, anastomotic leaks [30].…”

Section: Wound Infectionmentioning

confidence: 99%

Nutrition in Gynecologic Cancer

Cantrell

Saks

Grajales

et al. 2015

Curr Obstet Gynecol Rep

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Nutrition plays a role in every aspect of gynecologic cancer care from diagnosis to death. Unfortunately, the topic is not well researched in gynecology oncology and much that is known about nutrition comes from other disciplines. Nutrition and resultant body mass index (BMI) affects a patient's risk of diagnosis of a gynecologic malignancy, treatment tolerance, complications, and survival. Sadly, 20 % of patients with cancer die of malnutrition rather than their disease. However, not all malnourished patients are thin, as patients with BMIs in the obese range often do not have adequate nutrition. Recent literature challenges previous thoughts about feeding before and after surgery and clearly links obesity and diet quality with survival. More research is needed on the nutrition of patients with gynecologic malignancy, specifically how diet quality interfaces with the tolerance of radiation and chemotherapy.

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Immunonutrition: Role in Wound Healing and Tissue Regeneration

Cited by 101 publications

References 41 publications

Challenges in the Treatment of Chronic Wounds

Challenges in the Treatment of Chronic Wounds

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

Nutrition in Gynecologic Cancer

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