Is It Important to Deliver Enhanced Levels of Arginine to Critically Ill Patients?

Karhadkar, Sunil S.; Barbul, Adrian

doi:10.1016/b978-1-4160-5476-4.00065-1

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Arginine In Critical Illness1

Which Patients May Benefit From Arginine Supplementation?1

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2016

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Cited by 1 publication

(2 citation statements)

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“…Ischemic/reperfusion (I/R) injuries are not uncommon in critically ill patients, and arginine has been purported to limit endothelial dysfunction in I/R injury, suggesting an additional beneficial mechanism 31 . The rationale for arginine supplementation is well established in animal models where supplemental arginine decreased thymus involution, promoted wound healing and lymphocyte proliferation, improved resistance to bacterial infections, and improved survival in sepsis 32 …”

Section: Arginine In Critical Illnessmentioning

confidence: 99%

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When Is It Appropriate to Use Arginine in Critical Illness?

et al. 2016

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In health, arginine is considered a nonessential amino acid but can become an essential amino acid (ie, conditionally essential amino acid) during periods of metabolic or traumatic stress as endogenous arginine supply is inadequate to meet physiologic demands. Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. The purpose of this review is to (1) describe arginine metabolism and role in health and critical illness, (2) describe the relationship between arginine and asymmetric dimethylarginine, and (3) review studies of supplemental arginine in critically ill patients.

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Section: Arginine In Critical Illnessmentioning

confidence: 99%

“…In addition, arginine has a positive effect on wound healing. Supplemental arginine provides a substrate for collagen synthesis at the wound site; increases plasma insulin‐like growth factor, which mediates growth hormone; and stimulates T‐cell function toward wound healing 32 …”

Section: Which Patients May Benefit From Arginine Supplementation?mentioning

confidence: 99%