Meta-Analysis of Olfactory Function in Schizophrenia, First-Degree Family Members, and Youths At-Risk for Psychosis

Moberg, Paul J.; Kamath, Vidyulata; Marchetto, Dana M.; Calkins, Monica E.; Doty, Richard L.; Hahn, Chang Gyu; Borgmann‐Winter, Karin; Kohler, Christian G.; Gur, Raquel E.; Turetsky, Bruce I.

doi:10.1093/schbul/sbt049

Cited by 135 publications

(149 citation statements)

References 52 publications

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“…Repeated metaanalyses by Moberg and colleagues 15,16 have supported ubiquitous deficits across tasks of odour de tection, discrimination, hedonics, identification and memory in individuals with schizophrenia compared with healthy controls. CrespoFacorro and colleagues 17 found individuals with schizophrenia to demonstrate impairment in apprecia tion of both positive and negative olfactory hedonic ex tremes, with evidence of accompanying neural circuitry dys function, and smell identification deficits have also been linked to diminished social drive in this population.…”

Section: J Psychiatry Neurosci 2015;40(6)mentioning

confidence: 92%

Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Cieslak

Walsh‐Messinger

Stanford

et al. 2015

J Psychiatry Neurosci

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Section: J Psychiatry Neurosci 2015;40(6)mentioning

confidence: 92%

Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Cieslak

Walsh‐Messinger

Stanford

et al. 2015

J Psychiatry Neurosci

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“…For instance, it is well established that patients with schizophrenia, Parkinson's disease, and Alzheimer's disease often suffer from olfactory impairments, possibly, among others, due to dysregulation of the dopaminergic system (Moberg et al 1997(Moberg et al , 2014Doty 2012). Moreover, disturbances in color vision are found in various medical conditions involving altered dopaminergic synaptic transmission, such as Tourette syndrome (Melun et al 2001), Huntington's disease (Büttner et al 1994), Parkinson's disease (Pieri et al 2000), and in cocaine-dependent patients (Roy et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Perception in attention deficit hyperactivity disorder

Fuermaier

Hüpen

Vries

et al. 2017

ADHD Atten Def Hyp Disord

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A large body of research demonstrated that individuals with attention deficit hyperactivity disorder (ADHD) suffer from various neuropsychological deficits. In contrast, less is known and only divergent evidence exists on perceptual functions of individuals with ADHD. This is problematic as neuropsychological and perceptual functions are closely interrelated and are often difficult to disentangle in behavioral assessments. This study presents the conduct and results of a systematic literature review on perceptual functions in children and adults with ADHD. This review considers studies using psychophysical methods (objective measurements) and self-and informant reports (subjective measurements). Results indicate that individuals with ADHD have altered perceptual functions in various domains as compared to typically developing individuals. Increased perceptual functions in individuals with ADHD were found with regard to olfactory detection thresholds, whereas reduced perceptual functions were evident for aspects of visual and speech perception. Moreover, individuals with ADHD were found to experience discomfort to sensory stimuli at a lower level than typically developing individuals. Alterations of perceptual functions in individuals with ADHD were shown to be moderated by various factors, such as pharmacological treatment, cognitive functions, and symptom severity. We conclude by giving implications for daily life functioning and clinical practice.

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“…Patients with schizophrenia have significant olfactory impairments including difficulties with odor identification, detection threshold sensitivity, discrimination, and memory (Moberg et al, 2014). These deficits are associated with smaller olfactory bulbs, worsen over the course of the illness, and are present in unaffected family members (Moberg et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…These deficits are associated with smaller olfactory bulbs, worsen over the course of the illness, and are present in unaffected family members (Moberg et al, 2014). Because of these findings, olfactory deficits have been proposed as an endophenotype of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, because odor identification involves higher cognitive processes, odor identification is generally more impaired in schizophrenia than odor detection threshold (Moberg et al, 2014). One study found that while controlling for odor identification, worse odor detection levels correlated with lack of spontaneity in males and emotional withdrawal in females, factors that contribute to social isolation.…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia

Woolley

Lam

Chuang

et al. 2015

Psychoneuroendocrinology

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SummaryBackground-Olfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.Methods-To examine this model, we administered 40 IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3′,5′-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.Results-On the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls. ContributorsJosh Woolley designed the study and supervised all data collection and analysis and manuscript writing. Olivia Lam helped manage various aspects of the study including data collection and recruitment of participants and assisted with manuscript writing. Brandon Chuang assisted with data collection, data management, statistical analyses, and manuscript writing. Judith Ford consulted with the team about data analysis and helped edit the manuscript. Dan H. Mathalon assisted with study design and data analysis. Sophia Vinogradov assisted with study design and data analysis. All authors contributed to and have approved the final manuscript. Conflict of interest statementDan Mathalon is a consultant to Bristol Myers Squibb Inc. Sophia Vinogradov is a consultant to Brain Plasticity Institute. The remaining authors declare that they have no conflicts of interest. U.S. Department of Veterans Affairs VA Author ManuscriptVA Author Manuscript VA Author ManuscriptDiscussion-Our data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed.

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Meta-Analysis of Olfactory Function in Schizophrenia, First-Degree Family Members, and Youths At-Risk for Psychosis

Cited by 135 publications

References 52 publications

Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Perception in attention deficit hyperactivity disorder

Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia

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