Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Cieslak, Kristina; Walsh‐Messinger, Julie; Stanford, Arielle D.; Vaez-Azizi, Leila M.; Antonius, Daniel; Harkavy‐Friedman, Jill; Goetz, Deborah; Goetz, Raymond R.; Malaspina, Dolores

doi:10.1503/jpn.140268

Cited by 21 publications

(16 citation statements)

References 49 publications

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“…Despite these premises, it is unclear whether a decrease in the time spent in social interaction (dependent variable) indicates an anxiogenic effect or a social dysfunction. Given the robust effect of social anxiety on social function in schizophrenia (Cieslak et al, 2015), the role of social vs. non-social anxiety should not be overlooked. For instance, using a virtual reality social encounter task, Park et al, (2009) reported significantly higher anxiety in response to happy avatars in schizophrenic patients vs. healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia

Seillier

Giuffrida

2017

Behavioural Pharmacology

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Social withdrawal should not be considered a direct measure of the negative symptoms of schizophrenia as it may result not only from asociality (primary negative symptom) but also from other altered processes such as anxiety. To understand the contribution of these two factors to social deficit, we investigated whether the social withdrawal observed in the sub-chronic phencyclidine (PCP) rat model of schizophrenia could be attributed to increased anxiety. Compared to saline controls, PCP-treated rats (5 mg/kg, b.i.d. for 7 days, followed by a washout period) spent significantly less time in social interaction, but did not show anxiety-like behaviors in different relevant behavioral paradigms. In addition, their social deficit was not affected by a behavioral procedure known to reduce anxiety-like behavior (repeated exposure to the same partner) nor by systemic administration of the classical anxiolytic diazepam. In contrast, PCP-induced social withdrawal was reversed by the cannabinoid agonist CP55,940, a drug with known anxiogenic properties. Furthermore, when using the social approach task, PCP-treated animals performed similarly to control animals treated with diazepam, but not to those treated with the anxiogenic compound Pentylenetetrazole (PTZ). Taken together, our results indicate that PCP-induced social withdrawal cannot be attributed to increased anxiety. These data are discussed in the context of primary versus secondary negative symptoms and the deficit syndrome of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia

Seillier

Giuffrida

2017

Behavioural Pharmacology

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“… 9 , 11 , 14 In SZ, olfactory dysfunction is associated with negative and cognitive symptoms. 15 , 16 , 17 Furthermore, the OE contains cells of neuronal lineage at multiple stages of maturity. 18 , 19 This provides a unique opportunity to investigate aspects of neurodevelopment, which may have been derailed early in life in SZ.…”

Section: Introductionmentioning

confidence: 99%

Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium

et al. 2016

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Cognitive impairment is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures in neuronal tissues that associate with deficits are not well understood. We conducted nasal biopsy to obtain olfactory epithelium from patients with SZ and control subjects. The neural layers from the biopsied epithelium were enriched by laser-captured microdissection. We then performed an unbiased microarray expression study and implemented a systematic neuropsychological assessment on the same participants. The differentially regulated genes in SZ were further filtered based on correlation with neuropsychological traits. This strategy identified the SMAD 5 gene, and real-time quantitative PCR analysis also supports downregulation of the SMAD pathway in SZ. The SMAD pathway has been important in multiple tissues, including the role for neurodevelopment and bone formation. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies.

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“…Part 1 analyses revealed a significant relation ship between scores on the SPQB and scores on the SIAS, as well as the BIS Drive subscale. These were anticipated as previous literature has established the relationship between behavior inhibition and social anxiety in relation to schizophrenia symptom behaviors (Cieslak et al, 2015). Further, it is well established that individuals with schizophrenia also experience social anxiety and social dysfunction (Cieslak et al, 2015;FonsecaPedrero et al, 2009).…”

Section: Discussionmentioning

confidence: 87%

“…Negative symptoms including avolition, anhedonia, and blunted affect are also similar to symptoms of Asperger's syndrome and anxiety disorders, both of which also have been known coincide with olfactory identification deficits (Suzuki, Critchley, Rowe, Howlin, & Murphy, 2003). Individuals with schizophrenia, Asperger's syndrome, and anxiety disorders have been known to present significantly lower scores on hedonic evaluations of odorants as well (Auster et al, 2014;Cieslak et al, 2015;Ishizuka et al, 2010;Krusemark et al, 2013;Suzuki et al, 2003).…”

Section: Introductionmentioning

confidence: 93%

“…Previous literature has established that indi viduals with schizophrenia often have deficits in social cognition (Brown & Cohen, 2010;Cieslak et al, 2015;FonsecaPedrero, PaínoPiñeiro, LemosGiráldez, VillazónGarcía, & Muñiz, 2009;Gica, Poyraz, & Gulec, 2019). Social cognition has been defined as the ability to make sense of other's behaviors and to understand other's beliefs and intentions (Gica et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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The Values of Psychological Science: Student and Faculty Perspectives on Research Ethics

Corts¹,

Pham²

2019

PsiChiJournal

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is the International Honor So ci ety in Psychology, found ed in 1929. Its mission: "recognizing and promoting excellence in the science and application of psy chol ogy." (Note. Our new mission statement is available at http://www.psichi.org/?page=purpose) Mem ber ship is open to undergraduates, graduate students, faculty, and alumni mak ing the study of psy chol ogy one of their major interests and who meet Psi Chi's min i mum qual i fi ca tions. Psi Chi is a member of the As so cia tion of Col lege Honor So ci et ies (ACHS), and is an affiliate of the Ameri can Psy cho logi cal As so cia tion (APA) and the Association for Psy cho log i cal Science (APS). Psi Chi's sister honor society is Psi Beta, the na tion al honor society in psychology for com mu nity and junior colleges. Psi Chi functions as a federation of chap ters located at over 1,150 senior col leg es and universities around the world. The Psi Chi Central Office is lo cat ed in Chatta nooga, Ten nessee. A Board of Directors, com posed of psy chol o gy faculty who are Psi Chi members and who are elect ed by the chapters, guides the affairs of the Or ga ni za tion and sets pol i cy with the ap prov al of the chap ters. Psi Chi membership provides two major opportunities. The first of these is ac a dem ic rec og ni tion to all in duc tees by the mere fact of mem ber ship. The sec ond is the opportunity of each of the Society's local chapters to nourish and stim u late the pro fes sion al growth of all members through fellowship and activities de signed to augment and en hance the reg u lar cur ric u lum. In addition, the Or ga ni za tion provides programs to help achieve these goals including con ven tions, research awards and grants competitions, and publication opportunities. JOURNAL PURPOSE STATEMENT The twofold purpose of the Psi Chi Journal of Psychological Research is to foster and reward the scholarly efforts of Psi Chi members, whether students or faculty, as well as to provide them with a valuable learning experience. The articles published in the Journal represent the work of undergraduates, graduate students, and faculty; the Journal is dedicated to increasing its scope and relevance by accepting and involving diverse people of varied racial, ethnic, gender identity, sexual orientation, religious, and social class backgrounds, among many others. To further support authors and enhance Journal visibility, articles are now available in the PsycINFO ® , EBSCO ® , Crossref ® , and Google Scholar databases. In 2016, the Journal also became open access (i.e., free online to all readers and authors) to broaden the dissemination of research across the psychological science community.

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Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia

Cited by 21 publications

References 49 publications

Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia

Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia

Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium

The Values of Psychological Science: Student and Faculty Perspectives on Research Ethics

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